In these reviews Moringa Oleifera leaves are the most studied and have been shown to be beneficial in several chronic conditions, such as hypercholesterolemia, high blood pressure, diabetes, insulin resistance, non-alcoholic liver disease, cancer, and general inflammation. Overall, it is well documented that Moringa Oleifera leaves are a good strategy for various conditions associated with heart disease, diabetes, cancer, and fatty liver. Table 1 of the first link e presents a list of some bioactive components present in OM leaves, their postulated actions in the animal model used, their protection against a specific disease and the corresponding reference.
With respect to cancer, moringa (MO) has been studied for its chemopreventive properties and has been shown to inhibit the growth of several human cancer cells. Several studies have reported the ability of OM leaves to protect organisms and cells from oxidative DNA damage, associated with cancer and degenerative diseases. MO leaf extract was found to inhibit the viability of acute myeloid leukemia, acute lymphoblastic leukemia, and hepatocellular carcinoma cells. Several bioactive compounds, including 4-(α-l-rhamnosyloxy)benzyl isothiocyanate, niazimycin, and β-sitosterol-3-O-β-d-glucopyranoside present in MO, may be responsible for its anticancer properties. MO leaf extract has also been shown to be effective on pancreatic and breast cancer cells.
In pancreatic cells, MO was shown to suppress the growth of pancreatic cancer cells by inhibiting NF-ĸB signaling and increasing the efficacy of chemotherapy by enhancing the effect of the drug on these cells. The antiproliferative effects of MO were also demonstrated in breast cancer cells.
A recent study evaluated the effects of various extracts of Moringa Oleifera, including leaves and roots, and nanocomposite preparations of these compounds against HepG, breast MCF7 and colorectal HCT116/Caco2 cells. All of these preparations were effective in terms of their cytotoxic impact, measured by apoptosis. Several animal studies have also confirmed the effectiveness of Moringa Oleifera leaves in preventing cancer in rats with diethylnitrosamine-induced liver carcinomas and in suppressing azoxymethane-induced colon carcinogenesis in mice.
Moringa Oleifera is effective against dental infections. Antimicrobial research against microbes that cause dental infections has been carried out on M. oleifera leaves in both aqueous and ethanol extracts. This plant is reported to be active in vitro to inhibit various oral bacteria such as E. faecalis, S. mutans, P. gingivalis, S. aureus and C. albicans, and has been tested ex vivo. The chemical components contained in M. oleifera are phenolics, glucosinolates, flavonoids, fatty acids, esters, alkaloids, sterols, terpenes and several other compounds. Based on the pharmacological effects and chemical components contained in M. oleifera, this plant has the potential to be further developed to produce an antibacterial agent product, especially for dental health.
In these reviews Moringa Oleifera leaves are the most studied and have been shown to be beneficial in several chronic conditions, such as hypercholesterolemia, high blood pressure, diabetes, insulin resistance, non-alcoholic liver disease, cancer, and general inflammation. Overall, it is well documented that Moringa Oleifera leaves are a good strategy for various conditions associated with heart disease, diabetes, cancer, and fatty liver. Table 1 of the first link e presents a list of some bioactive components present in OM leaves, their postulated actions in the animal model used, their protection against a specific disease and the corresponding reference.
With respect to cancer, moringa (MO) has been studied for its chemopreventive properties and has been shown to inhibit the growth of several human cancer cells. Several studies have reported the ability of OM leaves to protect organisms and cells from oxidative DNA damage, associated with cancer and degenerative diseases. MO leaf extract was found to inhibit the viability of acute myeloid leukemia, acute lymphoblastic leukemia, and hepatocellular carcinoma cells. Several bioactive compounds, including 4-(α-l-rhamnosyloxy)benzyl isothiocyanate, niazimycin, and β-sitosterol-3-O-β-d-glucopyranoside present in MO, may be responsible for its anticancer properties. MO leaf extract has also been shown to be effective on pancreatic and breast cancer cells.
In pancreatic cells, MO was shown to suppress the growth of pancreatic cancer cells by inhibiting NF-ĸB signaling and increasing the efficacy of chemotherapy by enhancing the effect of the drug on these cells. The antiproliferative effects of MO were also demonstrated in breast cancer cells.
A recent study evaluated the effects of various extracts of Moringa Oleifera, including leaves and roots, and nanocomposite preparations of these compounds against HepG, breast MCF7 and colorectal HCT116/Caco2 cells. All of these preparations were effective in terms of their cytotoxic impact, measured by apoptosis. Several animal studies have also confirmed the effectiveness of Moringa Oleifera leaves in preventing cancer in rats with diethylnitrosamine-induced liver carcinomas and in suppressing azoxymethane-induced colon carcinogenesis in mice.
https://www.mdpi.com/2076-3921/6/4/91 (2017).--
https://www.mdpi.com/2076-3921/11/2/402 (2022).--
https://irdhjournals.com/ijtans/article/view/16 (2024).--
https://www.cell.com/heliyon/pdf/S2405-8440(24)04292-0.pdf (2024).--
https://www.cell.com/heliyon/pdf/S2405-8440(24)03838-6.pdf (2024).---
https://journals2.ums.ac.id/index.php/jnhm/article/view/4446 (2024).---
https://www.mdpi.com/2072-6643/16/6/757 (2024).--
Moringa Oleifera is effective against dental infections. Antimicrobial research against microbes that cause dental infections has been carried out on M. oleifera leaves in both aqueous and ethanol extracts. This plant is reported to be active in vitro to inhibit various oral bacteria such as E. faecalis, S. mutans, P. gingivalis, S. aureus and C. albicans, and has been tested ex vivo. The chemical components contained in M. oleifera are phenolics, glucosinolates, flavonoids, fatty acids, esters, alkaloids, sterols, terpenes and several other compounds. Based on the pharmacological effects and chemical components contained in M. oleifera, this plant has the potential to be further developed to produce an antibacterial agent product, especially for dental health.
https://www.mdpi.com/1424-8247/17/1/142 (2024).--