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Monosodium glutamate (MSG) is a silent killer. Research showed that MSG was associated with adverse side effects. Monosodium glutamate has been linked to obesity, metabolic disorders, Chinese restaurant syndrome, neurotoxic effects and harmful effects on reproductive organs, diabetes, hepatotoxic, neurotoxic and genotoxic effects. Different reports revealed increased hunger, food intake, and obesity in human subjects. Furthermore, administration of a high dose of more than 75 mg/kg MSG significantly elevated systolic blood pressure. There are reports of harmful effects such as oxidative stress, DNA damage, protein modification, and stromal cell lysis. the intake of monosodium glutamate. Ingestion of MSG has also been linked to Parkinson's disease, Alzheimer's disease, addiction, brain trauma, anxiety, stroke, depression and epilepsy. Available literature showed that increased consumption of MSG may be associated with adverse health effects.

The term "Chinese restaurant syndrome" (CRS) was first used more than four decades ago. At the onset of symptoms, patients experience discomfort such as a burning sensation in the neck, blisters on both arms and occasionally on the front of the chest, generalized weakness, fatigue and palpitations.

These symptoms occur 20 minutes after consuming a meal rich in MSG. Other symptoms that may appear later include flushing, dizziness, syncope, and facial pressure.

Insulin resistance and reduced glucose tolerance in rodents due to MSG consumption raise concerns about the development of obesity in humans consuming MSG.

In the same study, the authors were able to show that MSG induces a significant decrease in liver transaminases, indicating liver damage. Monosodium glutamate significantly increases the serum level of fasting glucose, insulin, triglycerides, total cholesterol, low-density lipoproteins and decreases the level of high-density lipoproteins. Exogenous MSG exacerbates lipopolysaccharide-induced neurobehavioral deficits, oxidative damage, neuroinflammation, and cholinergic dysfunction in the brain. Chronically elevated blood glutamate concentrations caused by high dietary intake invoke neurodegeneration processes that ultimately could cause post-traumatic stress disorder

It has been established that MSG damages male reproductive accessory organs such as the prostate and epididymis. Furthermore, it alters serum enzyme activities and serum testosterone levels, reduction in sperm count, sperm motility, sperm morphology and viability, imbalances in male reproductive hormones.

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