Known for its zesty, pungent flavor, this popular root vegetable has a long list of compounds that may help fight bacteria and lower your risk of diseases.
Horseradish is a spicy, flavorful herb that has been used for centuries to enhance the flavor of foods, aid digestion, and improve human health. Horseradish is a neglected and underutilized plant species (NUS), especially with regards to its potential benefits in improving human health. The roots of this plant have been known for centuries to provide effective treatments for various human health disorders and it has a long history of use in traditional medicine. Horseradish is a source of many biologically active compounds and its richness in phytochemicals has encouraged its recent use as a functional food. The medicinal benefits of horseradish are numerous and this plant should be promoted more as it is beneficial for human health. Glucosinolates or their degradation products, isothiocyanates, are responsible for most of the claimed medicinal effects. Recent studies have suggested that glucosinolates provide preventive and inhibitory influence on different types of cancer, and horseradish contains high amounts of these compounds. Other medicinal benefits of horseradish include its well-known antibacterial properties that are also attributed to isothiocyanates and its high content of other antioxidants that benefit human health. Additionally, horseradish contains enzymes that stimulate digestion, regulate bowel movement, and reduce constipation.
Different isolation techniques of horseradish roots and leaves isolates resulted in different yields of AITC, PEITC, and corresponding nitriles in the roots; While in the leaves, AITC was predominant regardless of the isolation method. Horseradish extract and distillates effectively inhibited a range of opportunistic pathogens, including the emerging food spoilage microorganisms as well as hospital multidrug-resistant ESKAPE strains. MHG proved to be the most active, inhibiting growth of MRSA, L. monocytogenes, clinical A. baumannii and fungi.
The volatile susceptibility testing clearly showed that the antimicrobial activity of horseradish roots extract and distillates arises from the combined activity of its three main volatiles, among which the PEITC was the most active. PEITC was also shown to be the most contributing to the cytotoxic activity against two cell lines.
Over the past decade, intensive research has been devoted to ITCs as they are recognized to be responsible for various biological activities (anticancer, antimicrobial, etc.). Their activity is usually investigated using pure compounds or as a part of volatile mixtures isolated from plants that commonly contain 2-3 major GSLs as their precursors. On the other hand, the synergistic effects of their combinations are scarcely studied. Thus, in order to better understand the mechanisms involved in ITCs interactions, more detailed studies that comprise a higher number of ITCs and their different proportions in the mixtures are necessary.
The antimicrobial efficacy of this substance has been confirmed both in vitro and in various clinical trials, with its primary efficacy being attributed to TIC. PEITC, AITC and BITC exhibit a wide range of health benefits, including potent anti-inflammatory, antioxidant and antimicrobial properties, along with notable anti-cancer potentials. In addition, its ability to modulate critical biochemical pathways, such as nuclear factor erythroid-related factor 2 (Nrf2)/Kelch-type ECH-associated protein 1 (Keap1), nuclear factor kappa-light-chain-enhancer of activated B cells ( NF-κB) and signal transducer and activator of transcription (STAT) pathways, shedding light on their involvement in cellular apoptosis and their intricate role in guiding immune responses.
I've always disdained horseradish for it's use in altering the pure aroma of steak. However, I'll eat it for my health. Thanks for sharing yet another great article on healing foods. I'm very grateful for all the work you freely share!
This is a great recipe but where do I find a trustworthy raw unfiltered apple cider vinegar? Not Bragg. They were bought out and it and what's being produced now looks filtered and watered down.
Horseradish is a spicy, flavorful herb that has been used for centuries to enhance the flavor of foods, aid digestion, and improve human health. Horseradish is a neglected and underutilized plant species (NUS), especially with regards to its potential benefits in improving human health. The roots of this plant have been known for centuries to provide effective treatments for various human health disorders and it has a long history of use in traditional medicine. Horseradish is a source of many biologically active compounds and its richness in phytochemicals has encouraged its recent use as a functional food. The medicinal benefits of horseradish are numerous and this plant should be promoted more as it is beneficial for human health. Glucosinolates or their degradation products, isothiocyanates, are responsible for most of the claimed medicinal effects. Recent studies have suggested that glucosinolates provide preventive and inhibitory influence on different types of cancer, and horseradish contains high amounts of these compounds. Other medicinal benefits of horseradish include its well-known antibacterial properties that are also attributed to isothiocyanates and its high content of other antioxidants that benefit human health. Additionally, horseradish contains enzymes that stimulate digestion, regulate bowel movement, and reduce constipation.
Different isolation techniques of horseradish roots and leaves isolates resulted in different yields of AITC, PEITC, and corresponding nitriles in the roots; While in the leaves, AITC was predominant regardless of the isolation method. Horseradish extract and distillates effectively inhibited a range of opportunistic pathogens, including the emerging food spoilage microorganisms as well as hospital multidrug-resistant ESKAPE strains. MHG proved to be the most active, inhibiting growth of MRSA, L. monocytogenes, clinical A. baumannii and fungi.
The volatile susceptibility testing clearly showed that the antimicrobial activity of horseradish roots extract and distillates arises from the combined activity of its three main volatiles, among which the PEITC was the most active. PEITC was also shown to be the most contributing to the cytotoxic activity against two cell lines.
Over the past decade, intensive research has been devoted to ITCs as they are recognized to be responsible for various biological activities (anticancer, antimicrobial, etc.). Their activity is usually investigated using pure compounds or as a part of volatile mixtures isolated from plants that commonly contain 2-3 major GSLs as their precursors. On the other hand, the synergistic effects of their combinations are scarcely studied. Thus, in order to better understand the mechanisms involved in ITCs interactions, more detailed studies that comprise a higher number of ITCs and their different proportions in the mixtures are necessary.
The antimicrobial efficacy of this substance has been confirmed both in vitro and in various clinical trials, with its primary efficacy being attributed to TIC. PEITC, AITC and BITC exhibit a wide range of health benefits, including potent anti-inflammatory, antioxidant and antimicrobial properties, along with notable anti-cancer potentials. In addition, its ability to modulate critical biochemical pathways, such as nuclear factor erythroid-related factor 2 (Nrf2)/Kelch-type ECH-associated protein 1 (Keap1), nuclear factor kappa-light-chain-enhancer of activated B cells ( NF-κB) and signal transducer and activator of transcription (STAT) pathways, shedding light on their involvement in cellular apoptosis and their intricate role in guiding immune responses.
https://www.mdpi.com/2218-273X/10/2/343 (2020).--
https://www.mdpi.com/2311-7524/7/7/167 (2021).--
https://www.sciencedirect.com/science/article/pii/S1043661824000513 (2024).--
I've always disdained horseradish for it's use in altering the pure aroma of steak. However, I'll eat it for my health. Thanks for sharing yet another great article on healing foods. I'm very grateful for all the work you freely share!
This is a great recipe but where do I find a trustworthy raw unfiltered apple cider vinegar? Not Bragg. They were bought out and it and what's being produced now looks filtered and watered down.