The American Heart Association released new guidelines that can reduce the number of adults eligible for statin therapy from 45.4 million to 28.3 million.
Evidence tells us that diet influences intestinal microbial composition, so bioactive supplements in the diet can positively regulate the microbiota and body weight. Rice bran (RB) is the byproduct of the rice milling process and an important food waste. RB contains phenolic acids, γ-oryzanol and tocopherols, compounds such as acylated steryl glucosides, flavonoids, resveratrol, several bioactive peptides with protease inhibitory properties and can regulate the activity of circulating peptide hormones such as glucagon-like peptide-1 ( GLP-1), an insulinotropic intestinal hormone. Dietary supplementation of these bioactive compounds has demonstrated improvements in vascular inflammation, endothelial function, hypertension, hyperlipidemia, and hyperglycemia by reducing free radical-mediated oxidative stress due to the synergistic effect of several derived compounds. γ-oryzanol has a beneficial effect on lipid metabolism, glucose metabolism and the cardiovascular system. RB also contains GABA. The gut microbiota influences almost all human physiological, biological and psychological conditions. Gut dysbiosis is associated with cardiovascular diseases, diabetes, cancers, inflammatory diseases and obesity. Studies revealed that RB supplementation helps normalize the host microbiome by reducing the abundance of pathogens and supporting the growth of beneficial microbes. RB derivatives could act as prebiotics that could promote normal and healthy microbial flora.
High consumption of fats and sugars contributes to the development of obesity and comorbidities, such as diabetes, cardiovascular and kidney diseases. Different strategies have been used to prevent these diseases associated with obesity, such as changes in eating habits and/or the addition of dietary components with anti-inflammatory and antioxidant properties, such as gamma-oryzanol (γOz) present mainly in the bran and rice germ
A diet high in fats and sugars presented weight gain with an increase in insulin, HOMA, glucose and triglycerides, in addition there were atrial and ventricular structural alterations, deterioration of systolic and diastolic function, decreased glomerular filtration rate and proteinuria. Gamma-oryzanol is significantly protective against effects on body weight, hypertriglyceridemia, non-alcoholic fatty liver, changes in intestinal microbiota and metabolites, and intestinal barrier injury, kidney damage, and against structural and functional alteration of the heart. Consumption of γ-oryzanol can reverse liposaccharide-induced cognitive and memory impairments by promoting antioxidant and anti-inflammatory molecular responses of the hippocampus. In addition, rice and its bioactive compounds have numerous health benefits, such as hepatoprotective, anti-inflammatory, neuroprotective, hypolipidemic, hypocholesterolemic, metabolic regulators, protective effects against cardiovascular diseases and obesity,
Evidence tells us that diet influences intestinal microbial composition, so bioactive supplements in the diet can positively regulate the microbiota and body weight. Rice bran (RB) is the byproduct of the rice milling process and an important food waste. RB contains phenolic acids, γ-oryzanol and tocopherols, compounds such as acylated steryl glucosides, flavonoids, resveratrol, several bioactive peptides with protease inhibitory properties and can regulate the activity of circulating peptide hormones such as glucagon-like peptide-1 ( GLP-1), an insulinotropic intestinal hormone. Dietary supplementation of these bioactive compounds has demonstrated improvements in vascular inflammation, endothelial function, hypertension, hyperlipidemia, and hyperglycemia by reducing free radical-mediated oxidative stress due to the synergistic effect of several derived compounds. γ-oryzanol has a beneficial effect on lipid metabolism, glucose metabolism and the cardiovascular system. RB also contains GABA. The gut microbiota influences almost all human physiological, biological and psychological conditions. Gut dysbiosis is associated with cardiovascular diseases, diabetes, cancers, inflammatory diseases and obesity. Studies revealed that RB supplementation helps normalize the host microbiome by reducing the abundance of pathogens and supporting the growth of beneficial microbes. RB derivatives could act as prebiotics that could promote normal and healthy microbial flora.
High consumption of fats and sugars contributes to the development of obesity and comorbidities, such as diabetes, cardiovascular and kidney diseases. Different strategies have been used to prevent these diseases associated with obesity, such as changes in eating habits and/or the addition of dietary components with anti-inflammatory and antioxidant properties, such as gamma-oryzanol (γOz) present mainly in the bran and rice germ
A diet high in fats and sugars presented weight gain with an increase in insulin, HOMA, glucose and triglycerides, in addition there were atrial and ventricular structural alterations, deterioration of systolic and diastolic function, decreased glomerular filtration rate and proteinuria. Gamma-oryzanol is significantly protective against effects on body weight, hypertriglyceridemia, non-alcoholic fatty liver, changes in intestinal microbiota and metabolites, and intestinal barrier injury, kidney damage, and against structural and functional alteration of the heart. Consumption of γ-oryzanol can reverse liposaccharide-induced cognitive and memory impairments by promoting antioxidant and anti-inflammatory molecular responses of the hippocampus. In addition, rice and its bioactive compounds have numerous health benefits, such as hepatoprotective, anti-inflammatory, neuroprotective, hypolipidemic, hypocholesterolemic, metabolic regulators, protective effects against cardiovascular diseases and obesity,
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