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Article that has a great projection for health. Nutritional Genomics that focuses on the interaction between the bioactive components of food and the genome. Nutrigenetics and Nutrigenomics. The influence of nutrients on the expression of f genes is called nutrigenomics, while the heterogeneous response of gene variants to nutrients, dietary components and developing nutraceuticals is called nutrigenetics. The ideal is that we would have the possibility of evaluating our genetic variants and polymorphisms, which can reveal diseases or a predisposition to suffer from them and in this way have more information for better personalization of the diet. We can also apply the phrase “experience is the mother of science”

Genetic variation affects dietary tolerances among human subpopulations and may also influence dietary requirements and increase the possibility of individualizing nutritional intake for optimal health and disease prevention based on an individual's genome.

By analyzing the potential genetic response of an individual to a set of nutrients, it will be possible to recommend an ideal treatment diet that acts synergistically as an adjuvant in the inhibition of processes associated with specific neoplasms. In the first article: “Role of Key Micronutrients from Nutrigenetic and Nutrigenomic Perspectives in Cancer Prevention” whose objective of this review is to evaluate and present the effects that some key components of micronutrients (vitamin A, vitamin C, vitamin D and selenium) and some Macronutrients (polyunsaturated fatty acids, prebiotics and probiotics) can be used in prevention and/or therapy. of different types of cancer.

https://www.mdpi.com/1648-9144/55/6/283 (2020).----

https://www.taylorfrancis.com/chapters/edit/10.1201/9781003415381-8/micronutrients-macronutrients-nutrigenomics-meghna-dutta-suddhasatwya-chatterjee (2024).---

https://academic.oup.com/nutritionreviews/advance-article-abstract/doi/10.1093/nutrit/nuad102/7249295?login=false (2023).---

This article will provide updated information on the fundamentals of personalized nutrition, specifically emphasizing the complex triangulation interaction between the microbiota, dietary metabolites and genes. Furthermore, it highlights the unique composition of the intestinal microbiota, its influence on nutrigenomics and the adaptation of dietary suggestions.

https://link.springer.com/article/10.1186/s40246-023-00561-w (2023).---

This review article demonstrates how adequate probiotic intake enhances beneficial bacteria and can relieve irritable bowel syndrome and prevent colorectal cancer in the long term. We also show how a diet rich in folic acid is essential for methylenetetrahydrofolate reductase (MTHFR) function, which reduces the risk of colorectal cancer. Additionally, we discuss how certain diets were associated with the development of certain cancers. For example, red and processed meats are highly associated with colorectal and prostate cancer. Modifying these diets significantly reduced the risk and improved the prognosis of these cancers, among many others. We also examine how micronutrients play a role in cancer prevention. Furthermore, we show how folic acid prevents DNA mutations by improving protein methylation processes. Finally, after a systematic review of countless articles on cancer etiology and prevention, we believe that diet should be a crucial feature in cancer prevention and treatment programs. In the future, healthy diets and micronutrients could even successively alter the probability of suffering from cancer-causing genetic mutations. It will also play a role in boosting treatment and improving the prognosis of diagnosed cancers.

https://link.springer.com/article/10.1186/s43141-023-0

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this is progress. In pre 1937 medicine, lactic acidosis was a diagnosis, i wonder if this is related to the understanding of lactate in our modern medicine?

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