The evidence reported by Dr. Mercola reveals an essential basis for health: the importance of an organic diet of fresh foods, not ultra-processed (hydrogenated fats and carcinogenic compounds), low in omega 6, fish (EPA, DHA, vitamins D and E), saturated fat from coconut and cattle and grass-fed products, fasting and exercise. These factors are decisive to avoid insulin resistance, obesity and metabolic diseases. Obesity and aging predispose to numerous overlapping chronic diseases. For example, metabolic abnormalities, including insulin resistance (IR) and type 2 diabetes (T2D), are important causes of morbidity and mortality. Low-grade chronic inflammation of tissues, such as the liver, visceral adipose tissue, and neurological tissues, is considered to contribute significantly to these chronic diseases. The intestinal barrier function, which is strongly implicated in the pathogenesis of obesity and age-related diseases.
The incidence of obesity and its related metabolic disorders has increased significantly in the last 3 decades, culminating in the current global epidemic of metabolic diseases and leading to a search for contributing factors. Exposure of the developing fetus/newborn to a typical Western diet increases the risk of obesity and metabolic disorders throughout life, creating an intergenerational cycle of metabolic diseases. In Western countries, this epidemic of metabolic diseases has coincided with a marked increase in the intake of omega-6 polyunsaturated fatty acids. Recent studies have emphasized the proadipogenic properties of omega-6 polyunsaturated fatty acids. Recent studies have shown that perinatal exposure to a diet rich in omega-6 polyunsaturated fatty acids results in a progressive accumulation of body fat over generations.
There is evidence supporting the hypothesis that omega-6 PUFAs have proadipogenic and prolipogenic properties, and exposure to a diet rich in omega-6 PUFAs during the first years of life has been shown to be sufficient to program mass gain. body fat in offspring.
This review reports on the evidence of the real benefit of fish consumption in the prevention of sarcopenia and the positive action on muscle mass of biological compounds present in fish. Fish improves glucose homeostasis, helping to prevent diabetes and metabolic syndrome, and has a positive impact on muscle mass preservation among the elderly, mediated by multiple mechanisms.
Experimental studies have suggested that omega-6 and omega-3 fatty acids cause divergent effects on body fat gain through mechanisms of adipogenesis, adipose tissue darkening, lipid homeostasis, brain-gut-adipose tissue axis, and, most importantly, systemic inflammation. Prospective studies clearly show an increased risk of obesity as the omega-6 fatty acid level and omega-6/omega-3 ratio increase in red blood cell (RBC) membrane phospholipids, whereas Membrane phospholipids of high omega-3 red blood cells are decreased. the risk of obesity. The omega-6/omega-3 ratio plays an important role in increasing the development of obesity through AA eicosanoid metabolites and hyperactivity of the cannabinoid system, which can be reversed with increased intake of eicosapentaenoic acid (EPA). and docosahexaenoic acid (DHA).
I found the interview highly confusing and somewhat at odds with previous advice given on this site. The speaker talked way too fast, at least for me - a layman on medical and nutritional matters. Reading the supporting text, I came away unclear as to exactly what one can eat in reality. I think the whole thing needs to be laid out far more clearly and simply. Just my 2 cents.
The evidence reported by Dr. Mercola reveals an essential basis for health: the importance of an organic diet of fresh foods, not ultra-processed (hydrogenated fats and carcinogenic compounds), low in omega 6, fish (EPA, DHA, vitamins D and E), saturated fat from coconut and cattle and grass-fed products, fasting and exercise. These factors are decisive to avoid insulin resistance, obesity and metabolic diseases. Obesity and aging predispose to numerous overlapping chronic diseases. For example, metabolic abnormalities, including insulin resistance (IR) and type 2 diabetes (T2D), are important causes of morbidity and mortality. Low-grade chronic inflammation of tissues, such as the liver, visceral adipose tissue, and neurological tissues, is considered to contribute significantly to these chronic diseases. The intestinal barrier function, which is strongly implicated in the pathogenesis of obesity and age-related diseases.
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16558 (2022)
The incidence of obesity and its related metabolic disorders has increased significantly in the last 3 decades, culminating in the current global epidemic of metabolic diseases and leading to a search for contributing factors. Exposure of the developing fetus/newborn to a typical Western diet increases the risk of obesity and metabolic disorders throughout life, creating an intergenerational cycle of metabolic diseases. In Western countries, this epidemic of metabolic diseases has coincided with a marked increase in the intake of omega-6 polyunsaturated fatty acids. Recent studies have emphasized the proadipogenic properties of omega-6 polyunsaturated fatty acids. Recent studies have shown that perinatal exposure to a diet rich in omega-6 polyunsaturated fatty acids results in a progressive accumulation of body fat over generations.
There is evidence supporting the hypothesis that omega-6 PUFAs have proadipogenic and prolipogenic properties, and exposure to a diet rich in omega-6 PUFAs during the first years of life has been shown to be sufficient to program mass gain. body fat in offspring.
https://journals.lww.com/co-endocrinology/Fulltext/2013/02000/Omega_6_polyunsaturated_fatty_acids_and_the_early.12.aspx (2013)
This review reports on the evidence of the real benefit of fish consumption in the prevention of sarcopenia and the positive action on muscle mass of biological compounds present in fish. Fish improves glucose homeostasis, helping to prevent diabetes and metabolic syndrome, and has a positive impact on muscle mass preservation among the elderly, mediated by multiple mechanisms.
https://www.mdpi.com/2072-6643/12/2/307 (2020)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710756/ (2021)
https://journals.sagepub.com/doi/full/10.1177/11786388211022378 (2022)
Experimental studies have suggested that omega-6 and omega-3 fatty acids cause divergent effects on body fat gain through mechanisms of adipogenesis, adipose tissue darkening, lipid homeostasis, brain-gut-adipose tissue axis, and, most importantly, systemic inflammation. Prospective studies clearly show an increased risk of obesity as the omega-6 fatty acid level and omega-6/omega-3 ratio increase in red blood cell (RBC) membrane phospholipids, whereas Membrane phospholipids of high omega-3 red blood cells are decreased. the risk of obesity. The omega-6/omega-3 ratio plays an important role in increasing the development of obesity through AA eicosanoid metabolites and hyperactivity of the cannabinoid system, which can be reversed with increased intake of eicosapentaenoic acid (EPA). and docosahexaenoic acid (DHA).
https://www.mdpi.com/2072-6643/8/3/128 (2016)
I found the interview highly confusing and somewhat at odds with previous advice given on this site. The speaker talked way too fast, at least for me - a layman on medical and nutritional matters. Reading the supporting text, I came away unclear as to exactly what one can eat in reality. I think the whole thing needs to be laid out far more clearly and simply. Just my 2 cents.
Hello,
Following the article I would like to ask you about one point
all the studies on CLA conjugated linoleic acids
show enormous advantages to consume CLA.
I don't understand if we should stay away from them anymore !!!!
thank Michel