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Although the appearance of gray hair is due to multiple causes, such as dietary vitamin deficiency, stress, hormonal problems, or physiological or senile changes, it is currently known that gray hair is associated, regardless of its origin, with the Bcl2 and Bcl genes. -w.

According to Karin Schallreuter of the University of Bradford in Britain, one cause of gray hair is excess hydrogen peroxide produced by hair cells.

At any age, hair cells produce a certain amount of hydrogen peroxide (H2O2). The enzyme catalase breaks down H2O2 into hydrogen and oxygen. But with age, catalase decreases, and peroxide has a more profound effect on hair discoloration.

Another enzyme, methionine sulfoxide reductase A and B (MSR A and B), helps hair follicles repair damage caused by hydrogen peroxide.

The combination of higher levels of hydrogen peroxide and lower levels of MSR A and B hinders the production of the enzyme tyrosinase, which facilitates the transfer of melanin to the hair roots.

Hair color depends mainly on the pigment melanin, and the manufacturing of this pigment takes place in melanosomes through the process of melanogenesis. Although research has expanded in recent years in terms of microscopic, biochemical (hormonal, enzymatic), and molecular changes that occur within the hair follicle/shaft. Genetic factors, obesity, hypothyroidism, intestinal diseases, and other diseases are related to gray hair. The relationship is reciprocal.

---1. Chronic constipation, anemia, or thyroid problems can also promote gray hair. In fact, hyperthyroidism is one of the main factors of aging.

---2. Nutrient deficiency and junk food: Deficient intake of vitamin B12, iodine, copper, zinc, catalase, iron, protein, amino acids and folic acid. Bad diet, cereals, sugars, junk food, causes a nutritional imbalance in the body. All of this causes intestinal dysbiosis and even intestinal permeability and autoimmune diseases.

This study reveals the association with vitamin B 12, folic acid and biotin deficiencies. Larger studies are recommended to reach a logical conclusion.

---3. Excessive use of chemical hair dye products, hair may have to suffer loss. The same goes for frequent users of electric hair dryers and straighteners.

----4. Smoking addiction: In some studies, it was concluded that active smokers tend to experience this problem in their 20s.

---5. Stress and anxiety take a toll on your hair causing premature graying. Both emotional stress and oxidation can be blamed for this. When you are stressed, the levels of vitamin B in your body drop considerably. Hair follicles are vulnerable to stress like our DNA.

---6. Catalase and glutathione peroxidase levels decrease, hydrogen peroxide. Elevated homocysteine can accelerate graying of hair, because it has been suggested to directly generate hydrogen peroxide.

---7. Low catalase may be a causal factor in diabetes, and atherosclerosis. Hydrogen peroxide damages pancreatic β cells and causes insulin resistance. Stress and lack of sleep lead to hair whitening by decreasing catalase. Astragalus is an effective method to prevent a stress-induced decrease in catalase. Heavy metals such as mercury and lead can also decrease catalase as can excess iron. Other useful supplements against gray hair are detailed in this link.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514791/ (2017).----

https://selfhack.com/blog/novel-solutions-to-prevent-graying-hair/ .---

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706993/ (2019).---

https://www.sciencedirect.com/science/article/pii/S1110260817300807 (2018).--

https://www.sciencedirect.com/science/article/abs/pii/S0190962214021409 (2016).--

Hair whitening and obesity are independently related to ascending aorta dilation in young-middle aged men https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526979/ (2019).--

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