The manufacturer is touting the drug as a convenient option for people without access to health care services. However, it carries potential health risks.
The purpose of this review is to highlight the evidence that progesterone is effective for hot flashes and night sweats (vasomotor symptoms, VMS), improves sleep, and is probably safe in menopausal women (more than 1 year since last menstruation). Methods include randomized controlled clinical trials (RCTs) supplemented by basic science, population-based, and observational data as necessary. The barrier to progesterone use is lack of awareness that concerns about the safety of estrogens, including "menopausal hormone therapy" (MHT), are not applicable to progesterone. In a single 3-month RCT, progesterone (300 mg at bedtime) was an effective treatment of VMS in 133 healthy menopausal women. It caused a 55% overall VMS decrease, no withdrawal-related VMS rebound, and a greater VMS decrease in 46 women with ≥50 moderate-intensity VMS/week. Progesterone is equally or more effective than estradiol in improving cardiovascular endothelial function and did not cause cardiovascular safety concerns in a 3-month RCT. An 8-year prospective cohort study (E3N) in more than 80,000 menopausal women demonstrated that progesterone prevented breast cancer in women treated with estrogen. Multiple RCTs confirm that progesterone (300 mg daily at bedtime) does not cause depression and improves deep sleep. In conclusion, progesterone effectively treats VMS, improves sleep, and may be the only therapy needed by symptomatic, menopausal women at a normal age and without osteoporosis. One study also reported that progesterone therapy may be especially applicable for perimenopausal women. with frequent night sweats, sleep problems and difficulties coping.
The decrease in vitamin C causes the creation of free radicals (ROS) that cause a lower production of nitric oxide, worsening the vascularization of the corpus luteum and preventing the normal production of progesterone. 750 mg/day of vitamin C also increases progesterone levels by 77% and improves endometrial thickness and fertility in 3 months.
Vitamin E: 400 IU per day of vitamin E: Increases progesterone production by 67% during the luteal phase. Improves the thickness of the endometrium.
Stimulating optimal circulation is one of the interventions scientifically proven to improve progesterone production. L-arginine and L-citrulline are very important for the synthesis of nitric oxide. Foods high in these two amino acids are watermelon, wild salmon, shrimp, meat from free-range animals,
L-arginine: 6 g/day increases progesterone by 71%. Together with 600 mg/day of vitamin E, it improves the thickness of the endometrium by increasing blood circulation in the radial artery.
Vitamin B6: The efficient dose is 50-100 mg/day of the active form of vitamin B6 (pyridoxal-5-phosphate).
Melatonin (1.5-3 mg/day before bed) improves progesterone levels. If insomnia or lack of rest is the cause of progesterone deficiency, melatonin supplementation may be indicated.
Vitamin B6 is especially necessary for the development of the corpus luteum. Alcohol is capable of destroying vitamin B6 and, even if you supplement, it can cause low levels of progesterone and predominance of estrogens in the blood. Oral contraceptives are, without a doubt, the most common cause of low levels of progesterone due to the reduction in vitamin B6 they cause.
Zinc favors the binding of progesterone to its receptors in the endometrium.
The increase in omega 3 fatty acids from seafood (blue fish, shellfish and seaweed) increases progesterone levels.
The purpose of this review is to highlight the evidence that progesterone is effective for hot flashes and night sweats (vasomotor symptoms, VMS), improves sleep, and is probably safe in menopausal women (more than 1 year since last menstruation). Methods include randomized controlled clinical trials (RCTs) supplemented by basic science, population-based, and observational data as necessary. The barrier to progesterone use is lack of awareness that concerns about the safety of estrogens, including "menopausal hormone therapy" (MHT), are not applicable to progesterone. In a single 3-month RCT, progesterone (300 mg at bedtime) was an effective treatment of VMS in 133 healthy menopausal women. It caused a 55% overall VMS decrease, no withdrawal-related VMS rebound, and a greater VMS decrease in 46 women with ≥50 moderate-intensity VMS/week. Progesterone is equally or more effective than estradiol in improving cardiovascular endothelial function and did not cause cardiovascular safety concerns in a 3-month RCT. An 8-year prospective cohort study (E3N) in more than 80,000 menopausal women demonstrated that progesterone prevented breast cancer in women treated with estrogen. Multiple RCTs confirm that progesterone (300 mg daily at bedtime) does not cause depression and improves deep sleep. In conclusion, progesterone effectively treats VMS, improves sleep, and may be the only therapy needed by symptomatic, menopausal women at a normal age and without osteoporosis. One study also reported that progesterone therapy may be especially applicable for perimenopausal women. with frequent night sweats, sleep problems and difficulties coping.
https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1472567 (2018).---
https://www.nature.com/articles/s41598-023-35826-w (2023).--
The decrease in vitamin C causes the creation of free radicals (ROS) that cause a lower production of nitric oxide, worsening the vascularization of the corpus luteum and preventing the normal production of progesterone. 750 mg/day of vitamin C also increases progesterone levels by 77% and improves endometrial thickness and fertility in 3 months.
Vitamin E: 400 IU per day of vitamin E: Increases progesterone production by 67% during the luteal phase. Improves the thickness of the endometrium.
Stimulating optimal circulation is one of the interventions scientifically proven to improve progesterone production. L-arginine and L-citrulline are very important for the synthesis of nitric oxide. Foods high in these two amino acids are watermelon, wild salmon, shrimp, meat from free-range animals,
L-arginine: 6 g/day increases progesterone by 71%. Together with 600 mg/day of vitamin E, it improves the thickness of the endometrium by increasing blood circulation in the radial artery.
Vitamin B6: The efficient dose is 50-100 mg/day of the active form of vitamin B6 (pyridoxal-5-phosphate).
Melatonin (1.5-3 mg/day before bed) improves progesterone levels. If insomnia or lack of rest is the cause of progesterone deficiency, melatonin supplementation may be indicated.
Vitamin B6 is especially necessary for the development of the corpus luteum. Alcohol is capable of destroying vitamin B6 and, even if you supplement, it can cause low levels of progesterone and predominance of estrogens in the blood. Oral contraceptives are, without a doubt, the most common cause of low levels of progesterone due to the reduction in vitamin B6 they cause.
Zinc favors the binding of progesterone to its receptors in the endometrium.
The increase in omega 3 fatty acids from seafood (blue fish, shellfish and seaweed) increases progesterone levels.
https://www.xeviverdaguer.com/es/la-progesterona-te-poder-cambiar-la-vida/ .--
https://www.osanasaludacademy.com/progesterona-ii/ .--
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