Humanity is immersed in the incidence of obesity and its related metabolic disorders that has increased significantly in the last 3 decades, culminating in the current global epidemic of metabolic diseases and leading to the search for contributing factors. Exposure of the developing fetus/newborn to a typical Western diet increases the risk of obesity and metabolic disorders throughout life, creating an intergenerational cycle of metabolic diseases. In Western countries, this epidemic of metabolic diseases has coincided with a marked increase in the intake of omega-6 polyunsaturated fatty acids. Recent studies reported by Dr. Mercola have emphasized the pro-adipogenic properties of omega-6 polyunsaturated fatty acids. Recent studies have shown that perinatal exposure to a diet rich in omega-6 polyunsaturated fatty acids results in progressive accumulation of body fat over generations.
There is evidence to support the hypothesis that omega-6 PUFAs have proadipogenic and prolipogenic properties, and exposure to a diet rich in omega-6 PUFAs during the first years of life has been shown to be sufficient to program mass gain. body fat in offspring.
Excessive consumption of Omega-6 polyunsaturated fatty acids (PUFAs) versus deficiency of EPA and DHA and saturated fats such as lard, butter, coconut oil in modern diets: the disturbing factor of their “balanced antagonistic metabolic functions” in the body human. The beneficial effects of the polyunsaturated fatty acids (omega-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are now highlighted by a large number of studies. They play a role in the suppression of inflammation, gene expression, cell membrane fluidity/permeability, immune functionality, and intracellular/exocellular signaling. The imbalance between ω-3 and ω-6 FAs in the modern Western diet appears to contribute to the marked increase in the incidence of metabolic diseases, such as DM, over the past 30 years. Preclinical studies indicate that ω-3 may have a positive effect on glucose metabolism through its hypoglycemic and insulin-sensitizing effects.
Humanity is immersed in the incidence of obesity and its related metabolic disorders that has increased significantly in the last 3 decades, culminating in the current global epidemic of metabolic diseases and leading to the search for contributing factors. Exposure of the developing fetus/newborn to a typical Western diet increases the risk of obesity and metabolic disorders throughout life, creating an intergenerational cycle of metabolic diseases. In Western countries, this epidemic of metabolic diseases has coincided with a marked increase in the intake of omega-6 polyunsaturated fatty acids. Recent studies reported by Dr. Mercola have emphasized the pro-adipogenic properties of omega-6 polyunsaturated fatty acids. Recent studies have shown that perinatal exposure to a diet rich in omega-6 polyunsaturated fatty acids results in progressive accumulation of body fat over generations.
There is evidence to support the hypothesis that omega-6 PUFAs have proadipogenic and prolipogenic properties, and exposure to a diet rich in omega-6 PUFAs during the first years of life has been shown to be sufficient to program mass gain. body fat in offspring.
Excessive consumption of Omega-6 polyunsaturated fatty acids (PUFAs) versus deficiency of EPA and DHA and saturated fats such as lard, butter, coconut oil in modern diets: the disturbing factor of their “balanced antagonistic metabolic functions” in the body human. The beneficial effects of the polyunsaturated fatty acids (omega-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are now highlighted by a large number of studies. They play a role in the suppression of inflammation, gene expression, cell membrane fluidity/permeability, immune functionality, and intracellular/exocellular signaling. The imbalance between ω-3 and ω-6 FAs in the modern Western diet appears to contribute to the marked increase in the incidence of metabolic diseases, such as DM, over the past 30 years. Preclinical studies indicate that ω-3 may have a positive effect on glucose metabolism through its hypoglycemic and insulin-sensitizing effects.
https://journals.lww.com/co-endocrinology/Fulltext/2013/02000/Omega_6_polyunsaturated_fatty_acids_and_the_early.12.aspx (2013).-----
https://link.springer.com/protocol/10.1007/978-1-4939-9882-1_3 (2020).----
https://www.hindawi.com/journals/jl/2021/8848161/ (2021).---
https://www.mdpi.com/1422-0067/24/13/10717 (2023).---
https://www.mdpi.com/2072-6643/15/12/2672 (2023).---