A meal of refined, devitalized carbohydrates and sugars with a high glycemic index are quickly converted to glucose in the blood. This overload can cause a reaction called glycation, in which excess sugar molecules adhere to the collagen fibers of the skin, bones, joints, etc., and lose their strength and flexibility.
Advanced glycation end products (AGEs) are non-enzymatic interactions between reducing sugars and amino groups in proteins, lipids and nucleic acids. In numerous diseases, such as diabetes, neuropathy, atherosclerosis, aging, nephropathy, retinopathy and chronic kidney disease, the accumulation of AGEs has been proposed as a pathogenic mechanism of inflammation, oxidative stress and structural tissue damage leading to chronic vascular problems. Current studies on AGE inhibition mainly focused on food processing.
Free fructose, in particular, is very pro-inflammatory, promoting AGEs and accelerating the aging process. It also promotes the type of dangerous growth of fat cells around vital organs that are the hallmark of diabetes and heart disease.
Degenerative diseases are affected in one way or another by glycation reactions. These reactions cause significant damage to the body, including atherosclerosis, cataract formation, neurological damage, diabetes, wrinkled and sagging skin.
Some studies link green tea with reducing glycation, and carnosine-based supplements have also proven effective in this regard.
Evidence demonstrated that carnosine supplementation had a beneficial impact on preventing sarcopenia, fatty liver disease, preserving cognitive abilities, and improving neurodegenerative disorders and possesses anticancer actions of carnosine. Carnosine (1) inhibits the proliferation of breast, ovarian, colon and leukemia cancer cells; (2) positively regulates the expression of proinflammatory molecules; (3) modulates cytokine secretion and (4) restores normal cellular homeostasis. Other evidence reports that oral carnosine may be helpful for cataracts, Alzheimer's disease and other forms of dementia, diseases of the digestive tract, and heart disease.
A meal of refined, devitalized carbohydrates and sugars with a high glycemic index are quickly converted to glucose in the blood. This overload can cause a reaction called glycation, in which excess sugar molecules adhere to the collagen fibers of the skin, bones, joints, etc., and lose their strength and flexibility.
Advanced glycation end products (AGEs) are non-enzymatic interactions between reducing sugars and amino groups in proteins, lipids and nucleic acids. In numerous diseases, such as diabetes, neuropathy, atherosclerosis, aging, nephropathy, retinopathy and chronic kidney disease, the accumulation of AGEs has been proposed as a pathogenic mechanism of inflammation, oxidative stress and structural tissue damage leading to chronic vascular problems. Current studies on AGE inhibition mainly focused on food processing.
Free fructose, in particular, is very pro-inflammatory, promoting AGEs and accelerating the aging process. It also promotes the type of dangerous growth of fat cells around vital organs that are the hallmark of diabetes and heart disease.
Degenerative diseases are affected in one way or another by glycation reactions. These reactions cause significant damage to the body, including atherosclerosis, cataract formation, neurological damage, diabetes, wrinkled and sagging skin.
Some studies link green tea with reducing glycation, and carnosine-based supplements have also proven effective in this regard.
Evidence demonstrated that carnosine supplementation had a beneficial impact on preventing sarcopenia, fatty liver disease, preserving cognitive abilities, and improving neurodegenerative disorders and possesses anticancer actions of carnosine. Carnosine (1) inhibits the proliferation of breast, ovarian, colon and leukemia cancer cells; (2) positively regulates the expression of proinflammatory molecules; (3) modulates cytokine secretion and (4) restores normal cellular homeostasis. Other evidence reports that oral carnosine may be helpful for cataracts, Alzheimer's disease and other forms of dementia, diseases of the digestive tract, and heart disease.
https://www.ch.cam.ac.uk/group/duer/research/collagen-glycation-and-diabetes (2023).----
https://www.science.org/doi/10.1126/sageke.2005.18.pe12 (2005),.----
https://link.springer.com/article/10.1007/s00726-018-2592-9 (2018).---
https://www.mdpi.com/1420-3049/26/6/1644 (2021).-----
https://www.sciencedirect.com/science/article/pii/S0167488921001713 (2021).---
https://www.ncbi.nlm.nih.gov/pubmed/17884275 .-------
https://www.ncbi.nlm.nih.gov/pubmed/17179517 .-------
http://link.springer.com/article/10.1023%2FA%3A1023855428130?LI=true .-------
http://2.mol.bio.msu.ru/biokhimiya/contents/v65/pdf/bcm_0856.pdf .-------
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069809/ (2023),..----
https://www.sciencedirect.com/science/article/abs/pii/S0141813023027095 (2023).--
https://www.mdpi.com/2072-6643/15/7/1770 (2023).--
https://www.sciencedirect.com/science/article/abs/pii/S0303720723002897 (2024).---