Mainstream media has distorted serotonin by calling it the 'happy hormone.' On the contrary, new research shows that high levels of it are linked to dementia.
Endotoxin levels in blood plasma are elevated during infections, intestinal inflammation, gum disease, and neurodegenerative disease.
The addition of high levels of endotoxin to the blood induces microglial activation, priming and/or tolerance, memory deficits, and loss of brain synapses and neurons. Endotoxin promotes amyloid β and tau aggregation and neuropathology, suggesting the possibility that endotoxin synergizes with different aggregating proteins to give different neurodegenerative diseases. In neurological diseases, endotoxin levels increase significantly both in the blood and in the brain, due to gum disease and/or alteration of the intestinal microbiota. which leads to accelerated systemic infection with action on neurological diseases.
This review reports that Gaba is a major inhibitory neurotransmitter in the central nervous system with modulation of synaptic transmission, promotion of neuronal development and relaxation, and prevention of insomnia, depression, and neurodegenerative diseases. Furthermore, various properties of Gaba have also been reported in non-neuronal peripheral tissues and organs due to antihypertension, antidiabetes, anticancer, antioxidant, anti-inflammatory, antimicrobial, antiallergic, hepatoprotective, reno-protection, and intestinal protection. Sprouted rice and fermented foods contain a significant amount of Gaba.
The physiological balance between excitation and inhibition in the brain is significantly affected in Alzheimer's disease (AD). GABA is the main inhibitory neurotransmission system in the mammalian brain. Dysregulation of glutamate and GABA.
It has been shown in multiple brain conditions.
As reported by Dr. Mercola, GABA deficiency is associated with anxiety, fear, depression, phobias, impulsivity, addictions, schizophrenia, irritable bowel, hypertension, tinnitus, chronic pain, migraines, allergies and muscle tension.
Factors that can prevent the efficient conversion of glutamate to GABA include a lack of cofactors (B6 and magnesium) and a lack of the enzyme glutamate decarboxylase, which converts glutamate to GABA. Infections and chronic stress inhibit the function of this enzyme. GABA and the vagus nerve collaborate to control how the gut microbiota affects brain function. The vagus nerve is also an important regulator of the immune response and appears to be important for microbiota-gut-brain communication.
Exercise at about 85% of your maximum heart rate, to be exact. GABA is closely associated with physical performance since both intrinsic factors (inflammation, apoptosis, mitochondria, calcium metabolism, etc.) and extrinsic factors (endocrine, nutritional status, immobility, etc.) contribute to progressively defective myogenesis and dysfunction. muscle during aging
Endotoxin levels in blood plasma are elevated during infections, intestinal inflammation, gum disease, and neurodegenerative disease.
The addition of high levels of endotoxin to the blood induces microglial activation, priming and/or tolerance, memory deficits, and loss of brain synapses and neurons. Endotoxin promotes amyloid β and tau aggregation and neuropathology, suggesting the possibility that endotoxin synergizes with different aggregating proteins to give different neurodegenerative diseases. In neurological diseases, endotoxin levels increase significantly both in the blood and in the brain, due to gum disease and/or alteration of the intestinal microbiota. which leads to accelerated systemic infection with action on neurological diseases.
https://link.springer.com/article/10.1186/s12974-019-1564-7 (2019).---
https://link.springer.com/chapter/10.1007/978-3-030-66376-6_3 (2021).---
https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00627-2 (2023).---
https://ui.adsabs.harvard.edu/abs/2023SPIE12384E..0LL/abstract (2023).--
https://www.mdpi.com/2072-6643/16/2/308 (2024).--
This review reports that Gaba is a major inhibitory neurotransmitter in the central nervous system with modulation of synaptic transmission, promotion of neuronal development and relaxation, and prevention of insomnia, depression, and neurodegenerative diseases. Furthermore, various properties of Gaba have also been reported in non-neuronal peripheral tissues and organs due to antihypertension, antidiabetes, anticancer, antioxidant, anti-inflammatory, antimicrobial, antiallergic, hepatoprotective, reno-protection, and intestinal protection. Sprouted rice and fermented foods contain a significant amount of Gaba.
https://www.mdpi.com/1420-3049/24/15/2678/htm (2019).----
Green tea, white tea, and oolong tea naturally have high amounts of GABA.
https://www.mcgill.ca/oss/article/health/gaba-supplements-glorious-gimmicky-or-just-garbage (2018).-----
The physiological balance between excitation and inhibition in the brain is significantly affected in Alzheimer's disease (AD). GABA is the main inhibitory neurotransmission system in the mammalian brain. Dysregulation of glutamate and GABA.
It has been shown in multiple brain conditions.
As reported by Dr. Mercola, GABA deficiency is associated with anxiety, fear, depression, phobias, impulsivity, addictions, schizophrenia, irritable bowel, hypertension, tinnitus, chronic pain, migraines, allergies and muscle tension.
Factors that can prevent the efficient conversion of glutamate to GABA include a lack of cofactors (B6 and magnesium) and a lack of the enzyme glutamate decarboxylase, which converts glutamate to GABA. Infections and chronic stress inhibit the function of this enzyme. GABA and the vagus nerve collaborate to control how the gut microbiota affects brain function. The vagus nerve is also an important regulator of the immune response and appears to be important for microbiota-gut-brain communication.
https://pubmed.ncbi.nlm.nih.gov/34769106/ (2021)
https://www.nature.com/articles/s41380-023-02140-w (2023).---
https://www.sciencedirect.com/science/article/abs/pii/S0889159123000594 (2023).--
https://www.sciencedirect.com/science/article/pii/S0753332223001324 (2023).-----
Exercise at about 85% of your maximum heart rate, to be exact. GABA is closely associated with physical performance since both intrinsic factors (inflammation, apoptosis, mitochondria, calcium metabolism, etc.) and extrinsic factors (endocrine, nutritional status, immobility, etc.) contribute to progressively defective myogenesis and dysfunction. muscle during aging
https://www.nature.com/articles/s41598-023-41628-x (2023)
https://www.sciencedaily.com/releases/2016/02/160225101241.htm (2016).----
Meditation and yoga can increase GABA production in your brain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769029/ (2015).-------
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111147/ (2015).----