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Capsanthin is found in peppers and in lesser amounts in ginger. The richest part in capsaicin is the placenta, which is the central white part of peppers with a content of 85%. The seeds contain 8%.

Among the main bioactive plant compounds in chili peppers, capsanthin is the main carotenoid in red peppers, responsible for their red color. Capsanthin accounted for 37%, zeaxanthin 8%, cucurbitaxanthin A 7%, capsorubin 3.2% and beta-carotene 9%. Capsanthin appears to possibly exert a potent inhibitory effect on colon carcinogenesis.

Violaxanthin is the main carotenoid antioxidant in yellow chili peppers. Lutein is more abundant in green chili peppers.

Peppers also contain the antioxidants sinapinic acid and ferulic acid that may help protect against various chronic diseases. Ferulic acid is a phytochemical commonly found in fruits and vegetables such as tomatoes, sweet corn, and rice bran. It exhibits a wide range of therapeutic effects against various diseases such as cancer, diabetes, cardiovascular, and neurodegenerative diseases. The antioxidant content of ripe (red) chili peppers is much higher than that of unripe (green) peppers

https://pubmed.ncbi.nlm.nih.gov/24065101/ (2013)

https://pubmed.ncbi.nlm.nih.gov/11312889/ (2001)

https://pubmed.ncbi.nlm.nih.gov/18188410/ (2007)

https://www.tandfonline.com/doi/abs/10.1080/87559120902956141 (2009)

Capsaicin and its potent analogous molecules. It shows a significant effect on cancer cell proliferation, apoptosis, cancer cell surveillance, growth arrest, and metastasis. Capsaicin with other natural dietary compounds has synergistic anticancer activities. Apoptosis, growth arrest, and metastasis.

Capsaicin has been shown to induce apoptosis in many different types of cancer cell lines, including pancreatic, colon, prostate, liver, esophageal, bladder, skin, leukemia, lung, and endothelial cells, while leaving normal cells unharmed. Capsaicin appears to induce apoptosis in over 40 different cancer cell lines.

Capsaicin has been shown to specifically inhibit mitochondrial NADPH oxidase activity initiating apoptosis and changing mitochondrial permeability with activation of pro-apoptotic pathways. Capsaicin was found to induce p53 phosphorylation by downregulating sirtuin 1, which is responsible for the initiation of apoptosis. Capsaicin downregulated β-catenin transcription, decreased its protein stability, and caused apoptosis of colorectal cancer cells.

Capsaicin and other compounds have synergistic anticancer properties. Combined with resveratrol, capsaicin facilitated apoptosis by elevating nitric oxide (NO) through a p53-dependent manner. Capsaicin shows a synergistic effect with the dietary phytoestrogen, genistein, by regulating AMPK and cyclooxygenase 2 in breast cancer cells. Capsaicin and indole-3-carbinol, abundantly present in cruciferous vegetables, work synergistically to induce apoptosis in colorectal cancer, by altering the transcriptional function of nuclear factor kappa B, p53, and apoptosis-related control genes. Capsaicin and brassinin, a form of indole derived from cruciferous vegetables, showed synergistic anticancer activity by suppressing MMP2 expression, enzymatic activities, and invasion and migration of prostate carcinoma cells.

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https://www.intechopen.com/books/capsicum/anticancer-effect-of-capsaicin-and-its-analogues (2020)

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Has anyone here pickled serranos with mustard seeds? I've tried it and I can't get it to taste like mustard. I've never pickled anything before.

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