As Dr. Mercola reports, liver detoxification is essential. This includes hormonal health, digestive health (including histamine breakdown), and kidney health support. The liver detoxifies fundamentally through a phase process: In phase I, lipophilic toxicants are transformed into reactive molecules through reduction, oxidation and hydrolysis, catalyzed by P-450 enzymes. In phase II, the toxic substances transformed in phase I are conjugated with other molecules to create a water-soluble compound that can be eliminated mainly by bile or urine, and Phase III is elimination. The liver filters 1.5 liters of blood per minute, eliminating 99% of the bacteria and toxins that arrive from the intestine through the portal vein.
----1. SULFATION. It is a very important route because a large part of the estrogens and derivatives are detoxified through this route. It consists of the union of a toxicant with a sulfate group activated by ATP. Foods and supplements with taurine, MSM, B6 and B12 are good contributors in this phase. Regulate Nrf2 in cells with R-lipoic acid, polyphenols and sulfur-based compounds from cruciferous vegetables and allium.
----2. CONJUGATION. It consists of the addition of an amino acid to the compound to be deactivated. The main amino acid in this route is taurine (taurine-conjugation: responsible for eliminating bile acids, for example tanocholic acid). Next in importance is glycine: less important in the detoxification of bile acids but it helps to detoxify petrochemical derivatives (for example solvents). The rest of the conjugatable amino acids (ornithine, cysteine, Arginine and Glutamine) are not so relevant. Taurine, NAC, glycine, Ornithine, B6 are effective at this stage.
----3. CONJUGATION (GST): The compound that is conjugated in this pathway is glutathione, composed of cysteine glycine and glutamic acid. Eliminates heavy metals, aromatic hydrocarbon compounds, polycycle organophosphates, epoxides, paracetamol, etc.-.
Nutrients that help increase glutathione:
1. Milk thistle. 2. Undenatured Whey Protein. 3. Sulfur foods: cabbages and allium. 4. NAC (acetyl cysterine). 5. α-lipoic acid. 6. Methylation (vitamins B6, B9, B12 and biotin). 7. Selenium. 8. Vitamin C and E. 9. cow liver.
In one study, biotin, choline, milk thistle extract, N-acetyl L-cysteine, alpha lipoic acid, broccoli green tea concentrate, extract and turmeric were administered. Plasma glutathione levels increased by 74 percent at the end of the study.
4. METHYLATION. It consists of the addition of a methyl group to the molecules that have to be eliminated. SAMe is a good methyl group donation molecule. Choline, lecithin and B12 help in this stage. Estrogens are removed from circulation through 3 routes: Sulfation, methylation and glucuronidation.
5. GLUCORONIDATION. Glucoronidation consists of the combination of the toxicant with glucuronic acid. Bilirubin from the degradation of the Heme group of hemoglobin is eliminated by glucuronidation. Artichoke and desmodium, cruciferae and allium, help in this stage.
6. ACETYLATION. Acetylation consists of a reaction that introduces an acetyl group whose cofactors are vitamin B2 and B5. Helps eliminate toxins such as benzodiazepines, histamine and aromatic amines.
Also highlight the importance of mitochondrial health in detoxification and disease prevention. (NAD+) deficiency has been found in metabolic and aging diseases. NAD+ produces its beneficial effects through multiple pathways, including mitigating mitochondrial alterations, DNA damage, and oxidative stress.
NAD+: THE MOLECULE OF YOUTH? + FACTORS THAT INCREASE IT
The best detoxification is to avoid poisoning as much as possible. Above all, take care of your diet, exercise, sleep and the ciacadian rhythms that regulate them. Heavy metals are a fundamental part because they are associated with many chronic and degenerative diseases. Some of the metals that are particularly detrimental to mitochondrial function are aluminum, arsenic, cesium, tin, and thallium. Other toxic metals that many people have in their bodies are cadmium, mercury and lead.
When you have heavy metal toxicity, your body often attracts electromagnetic fields. These in turn affect your metabolism and ability to effectively eliminate toxins and heavy metals.
Some strategies that are great for detoxifying you are a low-EMF, full-spectrum infrared sauna along with R-lipoic acid. Minerals such as magnesium, zinc, selenium, potassium and iodine are also important for detoxification
Myers also has an online program called "Myers Detox Protocol Course," which focuses on replenishing minerals lost during the detox process such as Magnesium and Zinc.
Zinc helps expel cadmium, a metal that causes more cancers than all other metals combined. Selenium also prevents viral replication and helps eliminate arsenic, beryllium, cadmium, mercury and silver. Potassium helps expel thallium. Iodine to displace fluorine..
Increase your glutathione levels, either with precursors (such as N-acetylcysteine [NAC] or whey protein) or a liposomal glutathione formula. Glutathione is the dominant substance that binds to mercury and helps remove it from your tissues, along with other heavy metals.
Regulate Nrf2 in cells with R-lipoic acid, polyphenols and sulfur-based compounds from cruciferous vegetables and allium. The Ayurvedic herb haritaki is beneficial, as are sulforaphane (broccoli seed extract) and allicin and diallyl disulfide (garlic). All of these regulate Nrf2 and help in detoxification.
DR. MED. DIETRICH KLINGHARDT M.D., PH.D., ON EFFECTIVE HOLISTIC HEAVY METAL DETOXIFICATION (CHELATION),..
As Dr. Mercola reports, liver detoxification is essential. This includes hormonal health, digestive health (including histamine breakdown), and kidney health support. The liver detoxifies fundamentally through a phase process: In phase I, lipophilic toxicants are transformed into reactive molecules through reduction, oxidation and hydrolysis, catalyzed by P-450 enzymes. In phase II, the toxic substances transformed in phase I are conjugated with other molecules to create a water-soluble compound that can be eliminated mainly by bile or urine, and Phase III is elimination. The liver filters 1.5 liters of blood per minute, eliminating 99% of the bacteria and toxins that arrive from the intestine through the portal vein.
----1. SULFATION. It is a very important route because a large part of the estrogens and derivatives are detoxified through this route. It consists of the union of a toxicant with a sulfate group activated by ATP. Foods and supplements with taurine, MSM, B6 and B12 are good contributors in this phase. Regulate Nrf2 in cells with R-lipoic acid, polyphenols and sulfur-based compounds from cruciferous vegetables and allium.
----2. CONJUGATION. It consists of the addition of an amino acid to the compound to be deactivated. The main amino acid in this route is taurine (taurine-conjugation: responsible for eliminating bile acids, for example tanocholic acid). Next in importance is glycine: less important in the detoxification of bile acids but it helps to detoxify petrochemical derivatives (for example solvents). The rest of the conjugatable amino acids (ornithine, cysteine, Arginine and Glutamine) are not so relevant. Taurine, NAC, glycine, Ornithine, B6 are effective at this stage.
----3. CONJUGATION (GST): The compound that is conjugated in this pathway is glutathione, composed of cysteine glycine and glutamic acid. Eliminates heavy metals, aromatic hydrocarbon compounds, polycycle organophosphates, epoxides, paracetamol, etc.-.
Nutrients that help increase glutathione:
1. Milk thistle. 2. Undenatured Whey Protein. 3. Sulfur foods: cabbages and allium. 4. NAC (acetyl cysterine). 5. α-lipoic acid. 6. Methylation (vitamins B6, B9, B12 and biotin). 7. Selenium. 8. Vitamin C and E. 9. cow liver.
In one study, biotin, choline, milk thistle extract, N-acetyl L-cysteine, alpha lipoic acid, broccoli green tea concentrate, extract and turmeric were administered. Plasma glutathione levels increased by 74 percent at the end of the study.
4. METHYLATION. It consists of the addition of a methyl group to the molecules that have to be eliminated. SAMe is a good methyl group donation molecule. Choline, lecithin and B12 help in this stage. Estrogens are removed from circulation through 3 routes: Sulfation, methylation and glucuronidation.
5. GLUCORONIDATION. Glucoronidation consists of the combination of the toxicant with glucuronic acid. Bilirubin from the degradation of the Heme group of hemoglobin is eliminated by glucuronidation. Artichoke and desmodium, cruciferae and allium, help in this stage.
6. ACETYLATION. Acetylation consists of a reaction that introduces an acetyl group whose cofactors are vitamin B2 and B5. Helps eliminate toxins such as benzodiazepines, histamine and aromatic amines.
https://askthescientists.com/qa/liver-detoxification-pathways/.—
https://www.integrativefamilypractice.com/blog/liver-detoxification .--
https://regenerahealth.com/blog/detoxificacion-hepatica-fases/ .---
https://integrative.ca/blog/3-phases-detoxification.-
https://www.drlamcoaching.com/blog/liver-detox-phases-what-to-expect/ .--
Also highlight the importance of mitochondrial health in detoxification and disease prevention. (NAD+) deficiency has been found in metabolic and aging diseases. NAD+ produces its beneficial effects through multiple pathways, including mitigating mitochondrial alterations, DNA damage, and oxidative stress.
NAD+: THE MOLECULE OF YOUTH? + FACTORS THAT INCREASE IT
https://selfhacked.com/blog/nad-important-increase/ (2024)
The best detoxification is to avoid poisoning as much as possible. Above all, take care of your diet, exercise, sleep and the ciacadian rhythms that regulate them. Heavy metals are a fundamental part because they are associated with many chronic and degenerative diseases. Some of the metals that are particularly detrimental to mitochondrial function are aluminum, arsenic, cesium, tin, and thallium. Other toxic metals that many people have in their bodies are cadmium, mercury and lead.
When you have heavy metal toxicity, your body often attracts electromagnetic fields. These in turn affect your metabolism and ability to effectively eliminate toxins and heavy metals.
Some strategies that are great for detoxifying you are a low-EMF, full-spectrum infrared sauna along with R-lipoic acid. Minerals such as magnesium, zinc, selenium, potassium and iodine are also important for detoxification
Myers also has an online program called "Myers Detox Protocol Course," which focuses on replenishing minerals lost during the detox process such as Magnesium and Zinc.
Zinc helps expel cadmium, a metal that causes more cancers than all other metals combined. Selenium also prevents viral replication and helps eliminate arsenic, beryllium, cadmium, mercury and silver. Potassium helps expel thallium. Iodine to displace fluorine..
Increase your glutathione levels, either with precursors (such as N-acetylcysteine [NAC] or whey protein) or a liposomal glutathione formula. Glutathione is the dominant substance that binds to mercury and helps remove it from your tissues, along with other heavy metals.
Regulate Nrf2 in cells with R-lipoic acid, polyphenols and sulfur-based compounds from cruciferous vegetables and allium. The Ayurvedic herb haritaki is beneficial, as are sulforaphane (broccoli seed extract) and allicin and diallyl disulfide (garlic). All of these regulate Nrf2 and help in detoxification.
DR. MED. DIETRICH KLINGHARDT M.D., PH.D., ON EFFECTIVE HOLISTIC HEAVY METAL DETOXIFICATION (CHELATION),..
http://docshare04.docshare.tips/files/17519/175192800.pdf .-----
HOW TO DETOX HEAVY METALS .--
https://thewholejourney.com/detox-heavy-metals/ .----
.----
BENEFITS OF USING A SAUNA.-
https://artofsauna.ca/7-sauna-health-benefits/ .----
METABOLIC DETOXIFICATION.--
https://www.lifeextension.com/protocols/metabolic-health/metabolic-detoxification.----
HEAVY METAL DETOXIFICATION.--
https://www.lifeextension.com/protocols/health-concerns/heavy-metal-detoxification.----
26 SUPPLEMENTS THAT MAY SUPPORT LIVER HEALTH.--
https://selfhacked.com/blog/liver-supplements/.-----
21 FOODS THAT MAY BE GOOD FOR THE LIVER.--
https://selfhacked.com/blog/liver-health-foods-supplements-good-bad-liver/.----
DANGERS OF HEAVY METALS AND HOW TO DO A HEAVY METAL DETOX
https://draxe.com/health/heavy-metal-detox/ .----
FOODS THAT HELP YOU TO DETOX FROM HARMFUL HEAVY METALS.--
https://loovfood.com/7-foods-that-help-you-to-detox-from-harmful-heavy-metals/ (2021)
https://www.healthline.com/health/heavy-metal-detox#diet