Research indicates an important role for vitamins D and K together in modulating immune responses and potentially reducing inflammation-related diseases.
Vitamin D plays a regulatory role in bone formation, carbohydrate metabolism, immune responses, and cardiovascular regulation. Research has linked vitamin D deficiency to the development of diabetes mellitus, hypertension, cancer and osteoporosis. Vitamin K has been associated with a reduced risk of osteoporosis, cancer, and cardiovascular disease (due to improved vascular elasticity). mVitamin D is involved in cancer prevention, brain development, mitochondrial energy generation, and cellular functions. respiratory and antioxidants. Vitamin K2 in the form of MK-7 has been shown to be a bioactive compound to regulate osteoporosis, atherosclerosis, diabetes, obesity, cancer, inflammatory diseases and covid-19.
Vitamin D exerts growth inhibitory effects on triple negative breast cancer (TNBC) cells that are complemented by simultaneous exposure to vitamin K2 (menaquinone-4) with cell cycle arrest, differentiation, apoptosis-
K2 supplementation is effective for the growth and metastasis of multiple cancer cell lines. Studies have shown that vitamin K2 can exhibit anti-cancer activity in various cancer cell lines, including leukemia, lung cancer, ovarian cancer, prostate cancer, hepatocellular cancer and bladder cancer.
Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential in various physiological and pathological processes, including cancer. Vitamin K intake has been inversely associated with cancer incidence and mortality in observational studies. Functions include steroid and xenobiotic receptor activation and regulation of oxidative stress, apoptosis, and autophagy.
In this review, vitamin K2-7 has beneficial health effects in osteoporosis, cardiovascular diseases, inflammation, cancer, Alzheimer's disease, diabetes and peripheral neuropathy. .
Furthermore, K2-7-mediated growth suppression in cancer cells through cell cycle arrest, autophagy and apoptosis, being also responsible for the suppression of pro-inflammatory mediators.
Research indicates an important role for vitamins D and K together in modulating immune responses and potentially reducing inflammation-related diseases.
Vitamin D plays a regulatory role in bone formation, carbohydrate metabolism, immune responses, and cardiovascular regulation. Research has linked vitamin D deficiency to the development of diabetes mellitus, hypertension, cancer and osteoporosis. Vitamin K has been associated with a reduced risk of osteoporosis, cancer, and cardiovascular disease (due to improved vascular elasticity). mVitamin D is involved in cancer prevention, brain development, mitochondrial energy generation, and cellular functions. respiratory and antioxidants. Vitamin K2 in the form of MK-7 has been shown to be a bioactive compound to regulate osteoporosis, atherosclerosis, diabetes, obesity, cancer, inflammatory diseases and covid-19.
https://www.mdpi.com/1422-0067/20/4/896/htm (2019).-----
https://www.sciencedirect.com/science/article/abs/pii/S0261561420306130 (2021).---
https://www.mdpi.com/2072-6643/13/11/3914/htm (2021).---
https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/bab.2312 (2022).---
https://www.tandfonline.com/doi/abs/10.1080/10408398.2021.1910481 (2022).--
https://www.taylorfrancis.com/chapters/edit/10.1201/9781003414025-2/vitamins-nutraceuticals-cancer-tushar-lokhande-komal-valve-subhash-shinde-khemchand-surana-ganesh-chaturbhuj (2024).- -
https://www.sciencedirect.com/science/article/abs/pii/B9780323913386000422 (2024).--
https://www.tandfonline.com/doi/full/10.2147/JIR.S445806 (2024).--
https://www.rupahealth.com/post/the-science-behind-taking-vitamin-d-and-k-together-for-enhanced-health-outcomes (2024).---
Vitamin D exerts growth inhibitory effects on triple negative breast cancer (TNBC) cells that are complemented by simultaneous exposure to vitamin K2 (menaquinone-4) with cell cycle arrest, differentiation, apoptosis-
https://www.sciencedirect.com/science/article/abs/pii/S0960076023000626 (2023).---
K2 supplementation is effective for the growth and metastasis of multiple cancer cell lines. Studies have shown that vitamin K2 can exhibit anti-cancer activity in various cancer cell lines, including leukemia, lung cancer, ovarian cancer, prostate cancer, hepatocellular cancer and bladder cancer.
https://www.spandidos-publications.com/10.3892/ijo.23.3.627 (2018).---
https://www.sciencedirect.com/science/article/abs/pii/S0899900718306300 (2019).--
https://link.springer.com/article/10.1007/s12282-019-01012-y (2019).--
https://www.nature.com/articles/s41598-020-64880-x (2020).--
https://www.sciencedirect.com/science/article/pii/B9780128119075000270 (2020).--
https://www.tandfonline.com/doi/full/10.2147/JIR.S445806 (2024).--
Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential in various physiological and pathological processes, including cancer. Vitamin K intake has been inversely associated with cancer incidence and mortality in observational studies. Functions include steroid and xenobiotic receptor activation and regulation of oxidative stress, apoptosis, and autophagy.
https://www.sciencedirect.com/science/article/abs/pii/S1471491422001824 (2022).---
In this review, vitamin K2-7 has beneficial health effects in osteoporosis, cardiovascular diseases, inflammation, cancer, Alzheimer's disease, diabetes and peripheral neuropathy. .
Furthermore, K2-7-mediated growth suppression in cancer cells through cell cycle arrest, autophagy and apoptosis, being also responsible for the suppression of pro-inflammatory mediators.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237441/ (2022).---
In this study, it was shown that vitamin K consumption is inversely related to the risk of lung cancer.
https://www.jstage.jst.go.jp/article/jea/advpub/0/advpub_JE20220063/_article/-char/ja/ (2023)