A necessary combination of vitamin D, K2 and magnesium. Vitamin K1 (VitK1) and vitamin K2 (VitK2), two important natural micronutrients found, respectively, in green leafy plants and algae (VitK1) and animal and fermented foods (VitK2). The present review explores the multiple biological functions of VitK2, including promoting osteogenesis, preventing calcification, alleviating menopausal symptoms, improving mitochondrial energy release, hepatoprotective and neuroprotective effects, cancer and the treatment of coronavirus disease. Several aspects of these VitK2 activities are discussed in the first report (Figure 2), and Table 1 summarizes the studies analyzed in this review that link VitK2 and health.
Additionally, this report reviews K2-7-mediated growth suppression in cancer cells through cell cycle arrest, autophagy, and apoptosis. The mechanistic basis of the disease modulatory effects of K2-7 is mediated by various signal transduction pathways such as PI3K/AKT, MAP Kinase, JAK/STAT, NF-κB, etc.
It is important to note that statins can prevent the conversion of vitamin K, ultimately affecting the functionality of vitamin K-dependent proteins. Unlike fat-soluble vitamins A and D, there is no specific plasma carrier protein for vitamin K. vitamin K. Instead, it is transported mainly in plasma by lipoproteins. Studies suggest a potential link between high-dose statin treatment and increased vascular calcification. One possible explanation is that statins may interfere with vitamin K-dependent protein synthesis, which plays a role in preventing calcification.
Additionally, certain studies have indicated that vitamin K supplementation has the potential to control hyperlipidemia, which could open a new avenue for controlling hyperlipidemia through the use of vitamin K dietary supplements. Overall, understanding the close relationship between vitamin K and lipids will provide better direction for studying and using vitamin K and may also offer a new intervention for hyperlipidemia.
Menaquinone-7 (MK-7 or K2-7) remains in the bloodstream longer and acts as an important cofactor in numerous biological processes. Furthermore, it is clinically proven to have numerous health benefits in the treatment of various diseases. Energy metabolism involves a complex biochemical process that produces energy from nutrients. This energy is necessary to perform different physiological functions, cellular processes, thermal homeostasis and organ function. Nutrients go through a series of metabolic pathways such as glycolysis, citric acid cycles, ß-oxidation and oxidative phosphorylation to produce energy in the form of adenosine triphosphate. These energy pathways are regulated by hormones and enzymes. Additionally, recent clinical studies have shown that K2-7 has been helpful in fat loss, suggesting the role of K2-7 in metabolism.
Joe, could you re-visit the discussion with our 'fav' Georgi over the difference of MK-7 vs MK-4 and your decision to suggest MK-7. Also, any negative issues with MK-4 supplementation.
A necessary combination of vitamin D, K2 and magnesium. Vitamin K1 (VitK1) and vitamin K2 (VitK2), two important natural micronutrients found, respectively, in green leafy plants and algae (VitK1) and animal and fermented foods (VitK2). The present review explores the multiple biological functions of VitK2, including promoting osteogenesis, preventing calcification, alleviating menopausal symptoms, improving mitochondrial energy release, hepatoprotective and neuroprotective effects, cancer and the treatment of coronavirus disease. Several aspects of these VitK2 activities are discussed in the first report (Figure 2), and Table 1 summarizes the studies analyzed in this review that link VitK2 and health.
https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.3213 (2023).--
Additionally, this report reviews K2-7-mediated growth suppression in cancer cells through cell cycle arrest, autophagy, and apoptosis. The mechanistic basis of the disease modulatory effects of K2-7 is mediated by various signal transduction pathways such as PI3K/AKT, MAP Kinase, JAK/STAT, NF-κB, etc.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.896920/full (2023).---
It is important to note that statins can prevent the conversion of vitamin K, ultimately affecting the functionality of vitamin K-dependent proteins. Unlike fat-soluble vitamins A and D, there is no specific plasma carrier protein for vitamin K. vitamin K. Instead, it is transported mainly in plasma by lipoproteins. Studies suggest a potential link between high-dose statin treatment and increased vascular calcification. One possible explanation is that statins may interfere with vitamin K-dependent protein synthesis, which plays a role in preventing calcification.
Additionally, certain studies have indicated that vitamin K supplementation has the potential to control hyperlipidemia, which could open a new avenue for controlling hyperlipidemia through the use of vitamin K dietary supplements. Overall, understanding the close relationship between vitamin K and lipids will provide better direction for studying and using vitamin K and may also offer a new intervention for hyperlipidemia.
https://link.springer.com/article/10.1186/s12986-023-00779-4 (2024).---
Menaquinone-7 (MK-7 or K2-7) remains in the bloodstream longer and acts as an important cofactor in numerous biological processes. Furthermore, it is clinically proven to have numerous health benefits in the treatment of various diseases. Energy metabolism involves a complex biochemical process that produces energy from nutrients. This energy is necessary to perform different physiological functions, cellular processes, thermal homeostasis and organ function. Nutrients go through a series of metabolic pathways such as glycolysis, citric acid cycles, ß-oxidation and oxidative phosphorylation to produce energy in the form of adenosine triphosphate. These energy pathways are regulated by hormones and enzymes. Additionally, recent clinical studies have shown that K2-7 has been helpful in fat loss, suggesting the role of K2-7 in metabolism.
https://openurl.ebsco.com/EPDB%3Agcd%3A1%3A22203233/detailv2?sid=ebsco%3Aplink%3Ascholar&id=ebsco%3Agcd%3A171358187&crl=c (2024).---
Joe, could you re-visit the discussion with our 'fav' Georgi over the difference of MK-7 vs MK-4 and your decision to suggest MK-7. Also, any negative issues with MK-4 supplementation.
Thanks, Dr. Greg