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Mar 4·edited Mar 4

In "New survey of vaccine-free group exposes long-term impact of vaccination policies on public health by Greg Glaser and Pat O’Connell" they found 10.7% of the children who were vaccinated had eczema while only 1.49% of the unvaccinated whose mothers took vitamin K shots at delivery had it, and the number of completely unvaccinated children and mothers was practically zero..

The study, found here:https://vaxxter.com/new-survey-of-vaccine-free-group-exposes-long-term-impact-of-vaccination-policies-on-public-health-by-greg-glaser-and-pat-oconnell/, shows the result on bar type graphs.

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Studies show that short-chain fatty acids (SCFAs) are signaling factors in the gut-skin axis and can alleviate skin inflammation. Recent studies have shown that SCFAs mitigate inflammation by regulating cytokine production by immune cells such as neutrophils, macrophages, dendritic cells (DCs), and T cells.

Short-chain fatty acids can affect cellular metabolism by promoting β-oxidation of mitochondrial fatty acids (FAO). Skin barrier dysfunction is a common pathological feature of inflammatory skin diseases. Recent studies have shown that SCFAs can improve the skin barrier and alleviate skin inflammation by altering metabolism and mitochondrial function. Butyrate is metabolized by epidermal keratinocytes, which in turn enhances the synthesis of keratinocyte-derived long-chain fatty acids (LCFAs) and very long-chain fatty acids (VLCFAs), a key event in the subsequent generation of ceramides. which are essential for the skin.

Spontaneous chronic urticaria (CSU) is a type of chronic inflammatory dermatosis driven predominantly by mast cells. Alterations in intestinal metabolites may exacerbate the inflammatory response and immune dysfunction during the pathogenesis of CSU. Furthermore, reduced SCFA accumulation due to an imbalance in intestinal flora may play an important role in the pathogenesis of CSU. Given the close correlation between SCFA expression and the occurrence of skin inflammation, SCFAs could be used to detect therapeutic efficacy and predict the prognosis of inflammatory skin diseases.

https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1083432/full (2023)

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Leaky gut syndrome and gut health issues can lead to histamine intolerance, oxalate intolerance, and salicylate intolerance. On the other hand, the buildup of histamine, oxalate, and salicylate causes increased inflammation, gut health issues, and leaky gut that lead to inflammation and health issues including in the skin.

Histamine is a chemical responsible for a multitude of functions in the body, including eliminating allergens as part of the immune response, communicating with the brain, and activating the release of stomach acid to aid digestion. While histamine is essential for health, too much histamine can create many problems. Histamine intolerance means you have too much histamine, which can lead to a variety of health problems.

Histamine intolerance affects the entire body, including the gut, brain, lungs, cardiovascular system, and hormonal health. Histamine intolerance can manifest itself in a variety of ways, including hormonal problems, headaches, skin problems, digestive problems, sleep disturbances, bladder problems, anxiety, rapid heart rate, seasonal allergies, and more.

Histamine intolerance can present itself in a variety of ways. The symptoms of histamine intolerance can often mimic other health problems, making them easy to misdiagnose or miss.

Symptoms of histamine intolerance include:

1) Diarrhea

2) Migraines and headaches

3) Eczema, psoriasis and other skin problems.

4) Blush

5) Hives

6) Tingling sensations on the skin or scalp.

7) Congestion or runny nose

8) Low blood pressure or hypertension

9) Tachycardia or racing heart

10) Fatigue

11) Asthma attacks

12) Abnormal menstrual cycle and menstrual problems.

13) Vertigo

14) Anxiety

https://ajcn.nutrition.org/article/S0002-9165(23)28053-3/fulltext

Salicylates are a group of chemicals. They are derived from salicylic acid. Naturally, they are found in plant foods. Foods and products high in salicylates do not cause problems for everyone, but for some they can cause salicylate intolerance and subsequent symptoms and health problems. In a healthy body, the liver helps detoxify excess salicylates; however, sluggish liver function may increase the risk of salicylate intolerance. Salicylates work similarly to oxalates. If your body reaches a high salicylate load and your body cannot break down all the excess salicylates. Excess salicylates can also cause overproduction of leukotrienes. Leukotrienes are inflammatory mediators that can increase the risk of a variety of health problems, such as asthma and inflammatory bowel disease. This can also lead to inhibition of cyclooxygenase production. Cyclooxygenase is an enzyme that regulates the production of leukotrienes.

Excess salicylates function very similarly in the body to excess oxalates. They can lead to inflammation, a compromised immune system, oxidative stress, poor mitochondrial function, cellular and tissue damage, and histamine release (more on this soon!). This can result in a list of symptoms and health problems including hives and skin problems. In the link.

https://pubmed.ncbi.nlm.nih.gov/21879102/ ----

https://pubmed.ncbi.nlm.nih.gov/16835707/ .--

https://pubmed.ncbi.nlm.nih.gov/14749606/

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