Fisetin has demonstrated several health benefits in preclinical models of neurodegenerative diseases such as Alzheimer's disease, vascular dementia, and schizophrenia. Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, stroke, traumatic brain injury (TBI), and age-related changes. This review also provides comprehensive data on recent, updated literature and highlights the various mechanistic pathways relevant to fisetin's neuroprotective role.
The effects of fisetin, a natural nutritional compound with promising potential, on obesity, cancer, neurological diseases, diabetes, and cardiovascular disease are brought to the attention of researchers with this review in light of real-world studies.
Fisetin reduces levels of the activator p35 cleavage product, which correlate with additional anti-inflammatory effects, including alterations in overall eicosanoid synthesis and the maintenance of synaptic function markers in mice with Alzheimer's disease.
In this article, fisetin was found to reduce cognitive deficits while restoring multiple markers associated with synaptic function, stress, and inflammation. These results provide further evidence of the potential benefits of fisetin for the treatment of age-related neurodegenerative diseases. https://www.ncbi.nlm.nih.gov/pubmed/28575152
Several preclinical studies have revealed that fisetin exhibits a wide range of pharmacological effects, including antioxidant, anti-inflammatory, anticancer, antiosteoporotic, antimicrobial, and antidiabetic properties.
Additional studies demonstrated that fisetin also possesses neurotrophic activity, a property that distinguishes it from other flavonoids tested. https://www.ncbi.nlm.nih.gov/pubmed/15312169
Fisetin reduces glycated proteins along with an elevation of the receptor for advanced glycation end products (RAGE), serum amyloid, and serum C-reactive protein, markers of protein oxidation, glycation, and inflammation.
In this systematic review, we gathered all available evidence supporting the anticancer potential of selected flavonols (kaempferol, fisetin, and myricetin) against bladder and prostate cancer.
In this review, we focused on the available evidence related to the regulation of PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB, and TRAIL/TRAIL-R by fisetin in different cancers.
Fisetin, as a polyphenol with pleiotropic pharmacological properties, showed promising anticancer activity in a wide range of cancers. Fisetin suppresses cancer cell stages, prevents cell cycle progression and cell growth, and induces apoptosis. Fisetin also inhibited cell division and cancer proliferation and invasion.
Flavonoids are emerging as potential therapeutic agents to mitigate senescence. Naringenin, hesperetin, hesperidin, quercetin, fisetin, kaempferol, rutin, apigenin, luteolin, nobiletin, tangeretin, genistein, wogonin, epigallocatechin gallate (EGCG), theaflavin-3-gallate (TF2A), and procyanidin C1 possess potent antisenescence effects. Flavonoids either directly modulate underlying cellular aging or senescence processes or interact with molecular targets that regulate aging-related pathways. This review analyzes the potential use of flavonoids to mitigate senescence and, consequently, delay the onset of aging-related diseases. https://link.springer.com/article/10.1007/s40290-022-00444-w (2022) .----
Fisetin was originally identified in a review of flavonoids that could prevent oxidative stress-induced nerve cell death. Of the 30 flavonoids tested in this study, fisetin was one of the most potent.
Fisetin is a flavonol from the flavonoid class, a group of polyphenols. It can be found in many plants, fruits, and vegetables. Strawberries have the highest fisetin content (160 mg/kg), five times higher than apples. The amount of fisetin in strawberries is approximately five times higher than in apples and, in general, more than 30 times higher than that found in mangoes, kiwis, grapes, tomatoes, onions, cucumbers, and various nuts.
Aging is a highly malleable process that can be modulated in a variety of ways, including calorie restriction, intermittent fasting, exercise, and a plant-based diet rich in phytochemicals. The use of bioactive compounds to eliminate senescent cells has recently emerged as a promising approach to delay aging and reduce the severity of chronic diseases. Among others, age-related neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), currently affect people worldwide. Plant-derived flavonoids have a wide range of activities that could make them particularly effective in blocking age-related toxicity pathways associated with neurodegenerative diseases. Fisetin has recently emerged as a potential anti-inflammatory, chemopreventive, chemotherapeutic, and senotherapeutic agent, making it a good candidate for the treatment of neurodegenerative diseases. This natural compound has recently been shown to modulate different pleiotropic pathways (phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and p38 mitogen-activated protein kinase (MAPK)-dependent nuclear factor-kappa light chain enhancer of activated B cells (NF-κB)) exerting a large number of biological effects including anti-inflammatory, hypolipidemic, hypoglycemic, antioxidant, neuroprotective, antiangiogenic, and antitumor effects. Fisetin acts as a senotherapeutic agent capable of prolonging lifespan, reducing ROS levels, and enhancing antioxidant cellular responses. This neuroprotection has been detected in in vitro and in vivo models associated with different neurological disorders. This review compiled the most recent findings on the antioxidant and neuroprotective effects of fisetin. This report is very comprehensive, addressing the mechanisms of aging.
In these reviews, fisetin emerged as one of the potential miracle molecules for addressing cognitive and neurobehavioral abnormalities. Fisetin is effective in neurodegenerative diseases such as Alzheimer's disease, vascular dementia, and schizophrenia, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, stroke, traumatic brain injury (TBI), and age-associated changes.
This review reports on the neuroprotective effects of fisetin, a naturally occurring flavonoid, in neurodegenerative diseases. Fisetin maintains mitochondrial redox profiles and functions. Fisetin regulates various metabolic pathways to prevent inflammatory responses and cytotoxicity. Fisetin's antioxidant properties protect neural cells from inflammation and apoptotic degeneration. Therefore, it can be used in the prevention of neurodegenerative disorders.
The effects of fisetin, a natural nutritional compound with promising potential, on obesity, cancer, neurological diseases, diabetes, and cardiovascular, bone, and macular degeneration diseases.
Fisetin has demonstrated several health benefits in preclinical models of neurodegenerative diseases such as Alzheimer's disease, vascular dementia, and schizophrenia. Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, stroke, traumatic brain injury (TBI), and age-related changes. This review also provides comprehensive data on recent, updated literature and highlights the various mechanistic pathways relevant to fisetin's neuroprotective role.
https://www.sciencedirect.com/science/article/abs/pii/S0014299921006464 (2021)
The effects of fisetin, a natural nutritional compound with promising potential, on obesity, cancer, neurological diseases, diabetes, and cardiovascular disease are brought to the attention of researchers with this review in light of real-world studies.
https://dergipark.org.tr/en/pub/jbachs/issue/58450/899925 (2020)
Fisetin reduces levels of the activator p35 cleavage product, which correlate with additional anti-inflammatory effects, including alterations in overall eicosanoid synthesis and the maintenance of synaptic function markers in mice with Alzheimer's disease.
http://onlinelibrary.wiley.com/doi/10.1111/acel.12185/ful
In this article, fisetin was found to reduce cognitive deficits while restoring multiple markers associated with synaptic function, stress, and inflammation. These results provide further evidence of the potential benefits of fisetin for the treatment of age-related neurodegenerative diseases. https://www.ncbi.nlm.nih.gov/pubmed/28575152
Several preclinical studies have revealed that fisetin exhibits a wide range of pharmacological effects, including antioxidant, anti-inflammatory, anticancer, antiosteoporotic, antimicrobial, and antidiabetic properties.
https://www.ncbi.nlm.nih.gov/pubmed/22234339
https://www.apjtb.org/article.asp?issn=2221-1691;year=2021;volume=11;issue=1;spage=1;epage=9;aulast=Antika (2021)
Additional studies demonstrated that fisetin also possesses neurotrophic activity, a property that distinguishes it from other flavonoids tested. https://www.ncbi.nlm.nih.gov/pubmed/15312169
Fisetin reduces glycated proteins along with an elevation of the receptor for advanced glycation end products (RAGE), serum amyloid, and serum C-reactive protein, markers of protein oxidation, glycation, and inflammation.
https://www.ncbi.nlm.nih.gov/pubmed/21738623
In this systematic review, we gathered all available evidence supporting the anticancer potential of selected flavonols (kaempferol, fisetin, and myricetin) against bladder and prostate cancer.
https://www.mdpi.com/2072-6643/13/11/3750/htm (2021)
In this review, we focused on the available evidence related to the regulation of PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB, and TRAIL/TRAIL-R by fisetin in different cancers.
https://www.sciencedirect.com/science/article/abs/pii/S1043661821003686 (2021)
Fisetin, as a polyphenol with pleiotropic pharmacological properties, showed promising anticancer activity in a wide range of cancers. Fisetin suppresses cancer cell stages, prevents cell cycle progression and cell growth, and induces apoptosis. Fisetin also inhibited cell division and cancer proliferation and invasion.
https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.1872 (2021)
The results of this study revealed that fisetin is a potent therapy for colorectal cancer, inhibiting trypsin both in vitro and in vivo.
https://europepmc.org/article/ppr/ppr304849 (2021)
Flavonoids are emerging as potential therapeutic agents to mitigate senescence. Naringenin, hesperetin, hesperidin, quercetin, fisetin, kaempferol, rutin, apigenin, luteolin, nobiletin, tangeretin, genistein, wogonin, epigallocatechin gallate (EGCG), theaflavin-3-gallate (TF2A), and procyanidin C1 possess potent antisenescence effects. Flavonoids either directly modulate underlying cellular aging or senescence processes or interact with molecular targets that regulate aging-related pathways. This review analyzes the potential use of flavonoids to mitigate senescence and, consequently, delay the onset of aging-related diseases. https://link.springer.com/article/10.1007/s40290-022-00444-w (2022) .----
Fisetin was originally identified in a review of flavonoids that could prevent oxidative stress-induced nerve cell death. Of the 30 flavonoids tested in this study, fisetin was one of the most potent.
https://www.ncbi.nlm.nih.gov/pubmed/11182299 .----
Fisetin is a flavonol from the flavonoid class, a group of polyphenols. It can be found in many plants, fruits, and vegetables. Strawberries have the highest fisetin content (160 mg/kg), five times higher than apples. The amount of fisetin in strawberries is approximately five times higher than in apples and, in general, more than 30 times higher than that found in mangoes, kiwis, grapes, tomatoes, onions, cucumbers, and various nuts.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/ .---
Aging is a highly malleable process that can be modulated in a variety of ways, including calorie restriction, intermittent fasting, exercise, and a plant-based diet rich in phytochemicals. The use of bioactive compounds to eliminate senescent cells has recently emerged as a promising approach to delay aging and reduce the severity of chronic diseases. Among others, age-related neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), currently affect people worldwide. Plant-derived flavonoids have a wide range of activities that could make them particularly effective in blocking age-related toxicity pathways associated with neurodegenerative diseases. Fisetin has recently emerged as a potential anti-inflammatory, chemopreventive, chemotherapeutic, and senotherapeutic agent, making it a good candidate for the treatment of neurodegenerative diseases. This natural compound has recently been shown to modulate different pleiotropic pathways (phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and p38 mitogen-activated protein kinase (MAPK)-dependent nuclear factor-kappa light chain enhancer of activated B cells (NF-κB)) exerting a large number of biological effects including anti-inflammatory, hypolipidemic, hypoglycemic, antioxidant, neuroprotective, antiangiogenic, and antitumor effects. Fisetin acts as a senotherapeutic agent capable of prolonging lifespan, reducing ROS levels, and enhancing antioxidant cellular responses. This neuroprotection has been detected in in vitro and in vivo models associated with different neurological disorders. This review compiled the most recent findings on the antioxidant and neuroprotective effects of fisetin. This report is very comprehensive, addressing the mechanisms of aging.
https://www.mdpi.com/1420-3049/27/3/738/htm (2022) .---
In these reviews, fisetin emerged as one of the potential miracle molecules for addressing cognitive and neurobehavioral abnormalities. Fisetin is effective in neurodegenerative diseases such as Alzheimer's disease, vascular dementia, and schizophrenia, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, stroke, traumatic brain injury (TBI), and age-associated changes.
https://www.sciencedirect.com/science/article/abs/pii/S0014299921006464 (2021).---
https://content.iospress.com/articles/brain-plasticity/bpl200104 (2020).---
This review reports on the neuroprotective effects of fisetin, a naturally occurring flavonoid, in neurodegenerative diseases. Fisetin maintains mitochondrial redox profiles and functions. Fisetin regulates various metabolic pathways to prevent inflammatory responses and cytotoxicity. Fisetin's antioxidant properties protect neural cells from inflammation and apoptotic degeneration. Therefore, it can be used in the prevention of neurodegenerative disorders.
https://europepmc.org/article/med/36299900 (2022)
The effects of fisetin, a natural nutritional compound with promising potential, on obesity, cancer, neurological diseases, diabetes, and cardiovascular, bone, and macular degeneration diseases.
https://dergipark.org.tr/en/pub/jbachs/issue/58450/899925 (2020) .-----
https://link.springer.com/chapter/10.1007/978-3-319-41334-1_10 (2016) .----
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009086/ (2021) .-----
https://dergipark.org.tr/en/pub/jbachs/issue/58450/899925 (2020) .-----
https://www.apjtb.org/article.asp?issn=2221-1691;year=2021;volume=11;issue=1;spage=1;epage=9;aulast=Antika (2021) .------
https://onlinelibrary.wiley.com/doi/full/10.1002/efd2.3 (2022) .-----
https://www.sciencedirect.com/science/article/abs/pii/S1471489222000406 (2022) .----
https://www.apjtb.org/article.asp?issn=2221-1691;year=2021;volume=11;issue=1;spage=1;epage=9;aulast=Antika (2021) .----