A great Armstrong project, offering offers milk, cheese, pork with low linoleic content with good contributions of choline, it has been proven that uridine found in the liver of animals, vegetables such as broccoli, breast milk and beer increases choline levels in the brain. Uridine and choline act synergistically with DHA to increase the formation of phosphatidylcholine. The latter is necessary to produce alphatidylcene (PC), a precursor of acetylcholine, the essential neurotransmitter in the brain.

It has been shown to boost mood, cognitive function, learning and memory.

-----1) Uridine is a key metabolite used as a substrate for the production of DNA, RNA and glucose,

-----2) Increases brain neurotransmitter levels

-----3) Reduce stress

-----4) Increases learning ability and memory

-----5) It is a regulator of energy balance, being a potential target to address eating behavior dysfunctions in humans.

----6) It has anti-cancer effects

-----7) Cardiovascular protector.

https://nootropicsexpert.com/uridine-monophosphate/ (2022).----

https://focussupplements.co.uk/es/2021/11/12/supplements-to-maximise-brain-health/ (2021).----

https://www.institutovalencianodeozonoterapia.com/papel-de-los-nucleotidos-en-la-recuperacion-de-la-neuropatia-periferica/ (2022).---

https://web.mit.edu/dick/www/pdf/1010.pdf (2022).--- https://www.sciencedirect.com/science/article/pii/S2666379122004761 (2023).---

https://www.nature.com/articles/s41574-023-00808-5 (2023).---

https://www.mdpi.com/2077-0383/12/10/3552 (2023).---

https://www.researchsquare.com/article/rs-2436173/v1 (2023).---

Foods and nutrients influence the microbiome in different ways. For example, a Western diet with a high consumption of processed fats and sugars high in linoleic acid reduces microbial diversity, produces dysbiosis and affects cognition by triggering chronic low-grade inflammation. Diet interacts with the host's genetics and microbiota, with physiological consequences that can protect or harm the brain.

The additive effects of the combination of DHA, uridine, choline, folate, vitamin B12, vitamin B6, vitamin E, vitamin C and selenium promotes synaptogenesis to counteract the synaptic loss that occurs in cognitive decline and AD. These ingredients may act through several synergistic mechanisms including, but not limited to, reducing homocysteine levels and increasing blood flow and cerebral perfusion.

Uridine and choline act synergistically with DHA to increase phosphatidylcholine formation, there is a compelling rationale for combining these nutrients. A multinutrient enriched with uridine, choline and DHA developed to support brain function has been evaluated in randomized controlled trials covering a spectrum of dementia from mild cognitive impairment to moderate AD.

https://www.cambridge.org/core/journals/nutrition-research-reviews/article/multinutrient-interventions-and-cognitive-ageing-are-we-barking-up-the-right-tree/EB20249CDC8BE6308A54DCB490ED7D64 (2022) .-----

https://link.springer.com/article/10.1007/s40120-020-00227-y (2020).----

https://link.springer.com/article/10.14283/jpad.2023.29 (2023).---

https://link.springer.com/article/10.14283/jpad.2023.81 (2023).---

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You are what you eat, eats.

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Thank you Guillermou.

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Pity it's not in Australia

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