Consider, as Dr. Mercola has reported, the relationship between ferritin and systemic inflammation, the origin of metabolic, cardiovascular and neurodegenerative diseases, including cancer. In cancer, higher levels correlate with aggressive disease and poor clinical outcome.
A diet deficient in copper and high in fructose markedly increased the level of iron in the liver, as well as the level of ferritin in plasma. In this review and studies, the role of copper-fructose interactions in the pathogenesis of metabolic syndrome, inflammation and NAFLD and the possible underlying mechanisms are discussed.
Elevated levels of ferritin and IL-6 also occur in individuals with high mortality due to SARS-CoV-2 infection. It is suggested that the optimal levels of ferritin for reducing cardiovascular mortality range between 20 and 80ng mL-1. Patients with severe to critical COVID-19 showed higher ferritin levels compared to patients with mild to moderate COVID-19 OR= 0.882.
Ferritin was initially described as an accompaniment to several acute infections, both viral and bacterial, indicating an acute response to inflammation.
Dr. Mercola informs us of the danger of high ferritin associated with GGT for health in general and liver and cardiovascular diseases in particular. It is also common to evaluate the status of the three transaminase enzymes GOT, GPT and GGT, as joint indicators of liver, pancreatic, cardiovascular, muscle, respiratory diseases and other causes. In the final evaluation, the relationships between the three transaminases are studied,
In addition to the most effective way to reduce ferritin with blood donation, Dr. Mercola good effectiveness of curcumin, lipoic acid and silymarin in iron chelation In these links other natural chelators such as quercetin, resveratrol, baicalin and catechins and tannins from green tea, and other phytochemicals and certain plants and herbs. The reducing action of iron is explained by its chelating action that blocks the absorption of iron from the diet, it can affect genetic expression to increase hepcidin and protect cells from damage from excess iron, helping to reduce the risks of diseases that cause high ferritin.
When you have hemochromatosis there is also a manganase overload besides the iron overload as iron and manganase share the same transport mechanisms.There is a very interesting article posted by Chris Masterjohn recently which I recommend you read.What causes the liver damage in hemochromatosis is more likely the manganase toxicity, so if you have hemochromatosis you should limit the foods high in manganase.
Consider, as Dr. Mercola has reported, the relationship between ferritin and systemic inflammation, the origin of metabolic, cardiovascular and neurodegenerative diseases, including cancer. In cancer, higher levels correlate with aggressive disease and poor clinical outcome.
https://www.sciencedirect.com/science/article/abs/pii/S0304419X13000395 (2013).---
https://link.springer.com/article/10.1186/s12933-022-01450-7 (2022).-----
https://link.springer.com/article/10.1007/s12035-020-02277-7 (2021).---
A diet deficient in copper and high in fructose markedly increased the level of iron in the liver, as well as the level of ferritin in plasma. In this review and studies, the role of copper-fructose interactions in the pathogenesis of metabolic syndrome, inflammation and NAFLD and the possible underlying mechanisms are discussed.
https://www.mdpi.com/2072-6643/10/11/1815 (2018)
https://journals.lww.com/eurojgh/Abstract/2022/04000/Serum_copper,_ceruloplasmin,_and_their_relations.13.aspx (2022).-----
Elevated levels of ferritin and IL-6 also occur in individuals with high mortality due to SARS-CoV-2 infection. It is suggested that the optimal levels of ferritin for reducing cardiovascular mortality range between 20 and 80ng mL-1. Patients with severe to critical COVID-19 showed higher ferritin levels compared to patients with mild to moderate COVID-19 OR= 0.882.
https://academic.oup.com/metallomics/article/13/6/mfab030/6287580?login=false (2021).---
https://www.sciencedirect.com/science/article/pii/S0883944121002185 (2021).---
This current meta-analysis evaluates the serum ferritin level at different levels of severity in COVID-19.
https://www.sciencedirect.com/science/article/pii/S0883944121002185
Ferritin was initially described as an accompaniment to several acute infections, both viral and bacterial, indicating an acute response to inflammation.
https://www.sciencedirect.com/science/article/pii/S0896841121001864 (2022).---
Dr. Mercola informs us of the danger of high ferritin associated with GGT for health in general and liver and cardiovascular diseases in particular. It is also common to evaluate the status of the three transaminase enzymes GOT, GPT and GGT, as joint indicators of liver, pancreatic, cardiovascular, muscle, respiratory diseases and other causes. In the final evaluation, the relationships between the three transaminases are studied,
https://www.emedicinehealth.com/liver_blood_tests/article_em.htm#diseases_that_cause_abnormal_aminotransferase_levels (2022).---
https://www.ncbi.nlm.nih.gov/books/NBK482489/ (2023).----
In addition to the most effective way to reduce ferritin with blood donation, Dr. Mercola good effectiveness of curcumin, lipoic acid and silymarin in iron chelation In these links other natural chelators such as quercetin, resveratrol, baicalin and catechins and tannins from green tea, and other phytochemicals and certain plants and herbs. The reducing action of iron is explained by its chelating action that blocks the absorption of iron from the diet, it can affect genetic expression to increase hepcidin and protect cells from damage from excess iron, helping to reduce the risks of diseases that cause high ferritin.
https://www.intechopen.com/chapters/77500#tab1 (2020).----
https://hemochromatosishelp.com/subscription-confirmed/ (2023).---
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821171/ (2009).---
https://www.mdpi.com/2075-1729/13/8/1730 (2023).----
https://www.sciencedirect.com/science/article/abs/pii/S0278691522007840 (2023).---
https://www.tandfonline.com/doi/abs/10.1080/10937404.2023.2224119 (2023).---
This review provides an analysis to demonstrate that curcumin imparts promising metal toxicity-enhancing effects.
https://www.mdpi.com/2076-3921/12/2/243 (2023).---
When you have hemochromatosis there is also a manganase overload besides the iron overload as iron and manganase share the same transport mechanisms.There is a very interesting article posted by Chris Masterjohn recently which I recommend you read.What causes the liver damage in hemochromatosis is more likely the manganase toxicity, so if you have hemochromatosis you should limit the foods high in manganase.