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Bob Paine's avatar

Great information, thanks!

There go the almond flour cookies and almonds.

Back to taking lemon juice like I did 20 years ago..

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Guillermou's avatar

Breast cancer is already the most diagnosed tumor in the world, with more than 2.2 million cases in 2020, surpassing lung cancer for the first time, according to data published in 2021 by the Center for Cancer Research. About one in 12 women will get breast cancer in their lifetime. Breast cancer is the leading cause of mortality in women.

In this study it is reported that chronic exposure of mammary epithelial cells to oxalate promotes transformation of mammary cells from normal to tumor cells, thereby inducing expression of a proto-oncogene such as c-fos and proliferation in breast cancer cells. . In addition, oxalate has a carcinogenic effect when it enters the mammary fat pad, generating undifferentiated and highly malignant tumors with characteristics of breast fibrosarcomas. As oxalates appear to promote these differences, it is expected that a significant reduction in the incidence of breast cancer tumors could be achieved if oxalate production or its carcinogenic activity could be controlled. It is important to note that treatment with potassium oxalate induced tumor formation more rapidly than treatment with calcium oxalate microcrystals, although the final oxalate concentration was the same in both cases. These differences are probably due to the fact that calcium oxalate is poorly soluble and the concentration of free oxalate, as an ion, at equilibrium is very low. On the other hand, potassium oxalate is highly soluble and all oxalate exists in its ionic form in solution at the concentrations used. Therefore, we conclude that free oxalate, as an ion, is the chemical species that has the carcinogenic effect on breast tissue.

https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1747-2 (2015)

Tables of oxalate content in food. The first link is a search engine.

TABLES OF OXALATE CONTENT IN FOOD. THE FIRST LINK IS A SEARCH ENGINE.

Metabolic reprogramming has been shown to be involved in cancer-induced premetastatic niche (PMN) formation. In this study we show that a rate-limiting enzyme of oxalate synthesis was upregulated in alveolar epithelial cells from mice with metastatic breast cancer cells at the premetastatic stage, leading to oxalate accumulation in the lung tissue. Pulmonary oxalate accumulation induced the formation of neutrophil extracellular traps (NETs) by activating NADPH oxidase, which facilitated the formation of a premetastatic niche. Furthermore, pulmonary oxalate accumulation promoted the proliferation of metastatic cancer cells by activating the MAPK signaling pathway.

https://www.nature.com/articles/s41388-022-02248-3 (2022)

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