Breast cancer is already the most diagnosed tumor in the world, with more than 2.2 million cases in 2020, surpassing lung cancer for the first time, according to data published in 2021 by the Center for Cancer Research. About one in 12 women will get breast cancer in their lifetime. Breast cancer is the leading cause of mortality in women.
In this study it is reported that chronic exposure of mammary epithelial cells to oxalate promotes transformation of mammary cells from normal to tumor cells, thereby inducing expression of a proto-oncogene such as c-fos and proliferation in breast cancer cells. . In addition, oxalate has a carcinogenic effect when it enters the mammary fat pad, generating undifferentiated and highly malignant tumors with characteristics of breast fibrosarcomas. As oxalates appear to promote these differences, it is expected that a significant reduction in the incidence of breast cancer tumors could be achieved if oxalate production or its carcinogenic activity could be controlled. It is important to note that treatment with potassium oxalate induced tumor formation more rapidly than treatment with calcium oxalate microcrystals, although the final oxalate concentration was the same in both cases. These differences are probably due to the fact that calcium oxalate is poorly soluble and the concentration of free oxalate, as an ion, at equilibrium is very low. On the other hand, potassium oxalate is highly soluble and all oxalate exists in its ionic form in solution at the concentrations used. Therefore, we conclude that free oxalate, as an ion, is the chemical species that has the carcinogenic effect on breast tissue.
Tables of oxalate content in food. The first link is a search engine.
TABLES OF OXALATE CONTENT IN FOOD. THE FIRST LINK IS A SEARCH ENGINE.
Metabolic reprogramming has been shown to be involved in cancer-induced premetastatic niche (PMN) formation. In this study we show that a rate-limiting enzyme of oxalate synthesis was upregulated in alveolar epithelial cells from mice with metastatic breast cancer cells at the premetastatic stage, leading to oxalate accumulation in the lung tissue. Pulmonary oxalate accumulation induced the formation of neutrophil extracellular traps (NETs) by activating NADPH oxidase, which facilitated the formation of a premetastatic niche. Furthermore, pulmonary oxalate accumulation promoted the proliferation of metastatic cancer cells by activating the MAPK signaling pathway.
Of course, Dr. Mercola always recommends a sufficient dietary intake of vitamin D, K2, calcium and magnesium and resorting to supplements if necessary until a blood vitamin D level of 50 to 70 is achieved.
Having an imbalance of these four nutrients, Dr. Mercola reported, is why calcium supplements are linked to increased risk of heart attacks and strokes, and why some people experience symptoms of vitamin D poisoning. Dr. Kate Rheaume-Bleue (whom I've interviewed on this topic) suggests taking 100-200 micrograms (mcg) of K2 for every 1,000 IU intake of vitamin D.
Some of the telltale signs of insufficient vitamin K2 are osteoporosis, heart disease, and diabetes. Also, you'll be more prone to deficiency if you don't regularly eat foods high in vitamin K2 (see the list below).
Vascular calcification is also a side effect of magnesium deficiency, so when taking vitamin D3, you'll need both vitamin K2 and magnesium to make sure everything is working properly.
As Dr. Mercola has reported in the link a summary of 25(OH)D DEFICIENCY AND DISEASE including breast, prostate and colorectal cancer, including lung disease and C-19.
Vitamin K intake has been inversely associated with cancer incidence and mortality in observational studies. Recently discovered functions of vitamin K in cancer cells include steroid and xenobiotic receptor (SXR) activation and regulation of oxidative stress, apoptosis, and autophagy. We provide an update on the biology of vitamin K, non-canonical mechanisms of vitamin K actions, potential roles of vitamin K-dependent proteins in cancer, and observational trials on vitamin K intake and cancer. .
The effects of vitamin K on selected female malignancies, i.e., breast cancer, cervical cancer, and ovarian cancer, have so far been observed mainly in in vitro and animal tests and have indicated various phenotypic effects exerted by different forms of the vitamin. Most studies have focused on the effects of vitamin K 2 and vitamin K 3 , there have been far fewer on vitamin K 1 . Exemplary effects of vitamin K on breast, cervical and ovarian cancers are schematically shown in Figure 3.
VK2 induced non-apoptotic cell death together with autophagy, in triple-negative breast cancer cell lines. The VK2-induced cell death phenotype appears to differ between cancer types.
Vitamin K is an important cofactor in the production of proteins that inhibit vascular calcification. A low intake of vitamin K in the diet has been associated with aortic and coronary calcifications and an elevated cardiovascular risk. Calcifications in the arteries of the breasts have also been associated with cardiovascular risk, but whether there is a relationship with a low intake of vitamin K has not yet been studied.
Vitamin K shows a multifaceted effect on the proper functioning of the human body: it prevents calcification of coronary vessels, maintains normal blood pressure, has neuroprotective effects, reduces the risk of myocardial infarction, slows the process of osteoclastogenesis, and influences the bone production resorption factors. The proapoptotic activity of menaquinone also affects other cancers such as glioblastoma multiforme, breast cancer or bladder cancer, which highlights the importance of vitamin K in oncology.
The most common cancers (in descending order of estimated number of new cases in 2020 are: breast cancer, lung and bronchial cancer, prostate cancer, colon and rectal cancer, melanoma (a skin cancer), bladder cancer, non-Hodgkin lymphoma, kidney and renal pelvis cancer, endometrial cancer, leukemia, pancreatic cancer, thyroid cancer, and liver cancer.
Prostate cancer, lung cancer, and colorectal cancer are estimated to account for 43% of all cancer diagnoses in men in 2020. The three most common cancers in women are: breast cancer, lung cancer and colorectal cancer. They are estimated to account for 50% of all new cancer diagnoses in women in 2020.
The increase in breast cancer is related to the ionic entry of oxalate into the fat pad of the breasts.
In this study the results demonstrate a positive correlation between urinary oxalate derived from endogenous oxalate synthesis and body mass index (BMI), as well as other measures of obesity. This also provides an explanation for the association between stone risk and obesity.
On the other hand, insulin resistance and obesity are related to inflammation and immune responses play an important role in the progression of prostate cancer. The cytotoxic function of NK cells for prostate cancer cells is inhibited by humoral factors in adipocytes. These local inflammatory cells are orchestrated by various signals from immune cells, fat cells, or prostate cancers. Prostate cancer cells stimulated by adipokines or saturated fatty acids could change the local immune profile in the context of obesity. Another possible mechanism to affect prostate cancer in obesity could be a gut microbiome. The high-fat diet changes the gut microbiome and improves colorectal cancer and liver cancer. The microbiome could modulate the host's immune system, and these changes in the immune system could have an effect on prostate cancer at a distance. Interventions to address systemic and/or local inflammation and a change in lifestyle may be therapeutic for prostate cancer
Common plant compounds that cause leaky gut include: Oxalates Histamines, Phytic acid, Lectins. Furthermore, a large proportion of grains, spices and nuts are contaminated with bacteria and mycotoxins (toxic moulds) which are also implicated in intestinal permeability.
Studies of the underlying epigenetic and molecular pathways reviewed in this chapter show that nickel compounds are both genotoxic and epigenotoxic, especially when cells are chronically exposed for prolonged periods of up to several weeks to allow sufficient nickel uptake. , with some lingering effects even after withdrawal. from exposure to nickel.
The excess of exogenous oxalates associated with the alteration of the AGXT (alanine-glyoxylate aminotransferase) gene encodes an enzyme that breaks down glyoxylate to the amino acid glycine, and when the enzyme is missing or decreased, glyoxylate is converted to oxalate.
Unfortunately, the inability to remove oxalates from your body can contribute to some serious (and painful!) health conditions, including: gout, kidney stones. joint pain and inflammation (similar to fibromyalgia or arthritis), insomnia, anxiety and depression, gastrointestinal problems. thyroid dysfunction, autoimmune disease. chronic inflammation, chronic candida, copd/asthma
Excess oxalates can also lead to oxidative damage and depletion of glutathione (your body's primary antioxidant and detoxifier). This can impair your ability to repair DNA and detoxify, resulting in cell mutation and heavy metal buildup! Also in the link problems related to histamine.
I am into real meat...Beef....90% and after eating beef and no vegetables I feel GREAT.....lost a lot of weight..pant size from 40 waist to now 34....lost a lot of bloat and sugar craving..and need to snack.....all gone. and I have not changed my way of life...except just started eating meat slowly eliminated the other stuff....now its beef some fruit and milk and honey....facts are I feel pretty good !!! and Im only 75.....
Doesn't milk actually make calcium leak from your bones and that's why people who had drunken milk scored high in calcium? And would citrate help with lectins in the almond milk?
Here is what Morley Robbins (Root Cause Protocol) says:
"I believe a body struggling w/ LOW Bioavailable Copper simply stores Oxalate><Iron in the Tissue as it LACKS the ANTI-OXIDANT capacity, NOR THE ENERGY to remove the excess Iron...
In the Plant world, plants USE Oxalates to BIND UP excess Iron & dissolve Oxalates w/ an Enzyme, Oxalate Oxidase. The STRONGEST Oxidase in the Body is Ceruloplasmin, which will be low if you have High Iron & Low Copper..."
Breast cancer is already the most diagnosed tumor in the world, with more than 2.2 million cases in 2020, surpassing lung cancer for the first time, according to data published in 2021 by the Center for Cancer Research. About one in 12 women will get breast cancer in their lifetime. Breast cancer is the leading cause of mortality in women.
In this study it is reported that chronic exposure of mammary epithelial cells to oxalate promotes transformation of mammary cells from normal to tumor cells, thereby inducing expression of a proto-oncogene such as c-fos and proliferation in breast cancer cells. . In addition, oxalate has a carcinogenic effect when it enters the mammary fat pad, generating undifferentiated and highly malignant tumors with characteristics of breast fibrosarcomas. As oxalates appear to promote these differences, it is expected that a significant reduction in the incidence of breast cancer tumors could be achieved if oxalate production or its carcinogenic activity could be controlled. It is important to note that treatment with potassium oxalate induced tumor formation more rapidly than treatment with calcium oxalate microcrystals, although the final oxalate concentration was the same in both cases. These differences are probably due to the fact that calcium oxalate is poorly soluble and the concentration of free oxalate, as an ion, at equilibrium is very low. On the other hand, potassium oxalate is highly soluble and all oxalate exists in its ionic form in solution at the concentrations used. Therefore, we conclude that free oxalate, as an ion, is the chemical species that has the carcinogenic effect on breast tissue.
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1747-2 (2015)
Tables of oxalate content in food. The first link is a search engine.
TABLES OF OXALATE CONTENT IN FOOD. THE FIRST LINK IS A SEARCH ENGINE.
Metabolic reprogramming has been shown to be involved in cancer-induced premetastatic niche (PMN) formation. In this study we show that a rate-limiting enzyme of oxalate synthesis was upregulated in alveolar epithelial cells from mice with metastatic breast cancer cells at the premetastatic stage, leading to oxalate accumulation in the lung tissue. Pulmonary oxalate accumulation induced the formation of neutrophil extracellular traps (NETs) by activating NADPH oxidase, which facilitated the formation of a premetastatic niche. Furthermore, pulmonary oxalate accumulation promoted the proliferation of metastatic cancer cells by activating the MAPK signaling pathway.
https://www.nature.com/articles/s41388-022-02248-3 (2022)
Of course, Dr. Mercola always recommends a sufficient dietary intake of vitamin D, K2, calcium and magnesium and resorting to supplements if necessary until a blood vitamin D level of 50 to 70 is achieved.
Having an imbalance of these four nutrients, Dr. Mercola reported, is why calcium supplements are linked to increased risk of heart attacks and strokes, and why some people experience symptoms of vitamin D poisoning. Dr. Kate Rheaume-Bleue (whom I've interviewed on this topic) suggests taking 100-200 micrograms (mcg) of K2 for every 1,000 IU intake of vitamin D.
Some of the telltale signs of insufficient vitamin K2 are osteoporosis, heart disease, and diabetes. Also, you'll be more prone to deficiency if you don't regularly eat foods high in vitamin K2 (see the list below).
Vascular calcification is also a side effect of magnesium deficiency, so when taking vitamin D3, you'll need both vitamin K2 and magnesium to make sure everything is working properly.
As Dr. Mercola has reported in the link a summary of 25(OH)D DEFICIENCY AND DISEASE including breast, prostate and colorectal cancer, including lung disease and C-19.
https://connieeash.com/vitamin-d-the-science/
Vitamin K intake has been inversely associated with cancer incidence and mortality in observational studies. Recently discovered functions of vitamin K in cancer cells include steroid and xenobiotic receptor (SXR) activation and regulation of oxidative stress, apoptosis, and autophagy. We provide an update on the biology of vitamin K, non-canonical mechanisms of vitamin K actions, potential roles of vitamin K-dependent proteins in cancer, and observational trials on vitamin K intake and cancer. .
https://www.sciencedirect.com/science/article/abs/pii/S1471491422001824 (2022)
The effects of vitamin K on selected female malignancies, i.e., breast cancer, cervical cancer, and ovarian cancer, have so far been observed mainly in in vitro and animal tests and have indicated various phenotypic effects exerted by different forms of the vitamin. Most studies have focused on the effects of vitamin K 2 and vitamin K 3 , there have been far fewer on vitamin K 1 . Exemplary effects of vitamin K on breast, cervical and ovarian cancers are schematically shown in Figure 3.
https://www.mdpi.com/2072-6643/14/16/3401 (2022)
VK2 induced non-apoptotic cell death together with autophagy, in triple-negative breast cancer cell lines. The VK2-induced cell death phenotype appears to differ between cancer types.
https://link.springer.com/article/10.1007/s12282-019-01012-y (2021)
Vitamin K is an important cofactor in the production of proteins that inhibit vascular calcification. A low intake of vitamin K in the diet has been associated with aortic and coronary calcifications and an elevated cardiovascular risk. Calcifications in the arteries of the breasts have also been associated with cardiovascular risk, but whether there is a relationship with a low intake of vitamin K has not yet been studied.
https://www.sciencedirect.com/science/article/abs/pii/S0378512206003148 (2007)
Vitamin K shows a multifaceted effect on the proper functioning of the human body: it prevents calcification of coronary vessels, maintains normal blood pressure, has neuroprotective effects, reduces the risk of myocardial infarction, slows the process of osteoclastogenesis, and influences the bone production resorption factors. The proapoptotic activity of menaquinone also affects other cancers such as glioblastoma multiforme, breast cancer or bladder cancer, which highlights the importance of vitamin K in oncology.
https://ojs.pum.edu.pl/pomjlifesci/article/view/477 (2020
The most common cancers (in descending order of estimated number of new cases in 2020 are: breast cancer, lung and bronchial cancer, prostate cancer, colon and rectal cancer, melanoma (a skin cancer), bladder cancer, non-Hodgkin lymphoma, kidney and renal pelvis cancer, endometrial cancer, leukemia, pancreatic cancer, thyroid cancer, and liver cancer.
Prostate cancer, lung cancer, and colorectal cancer are estimated to account for 43% of all cancer diagnoses in men in 2020. The three most common cancers in women are: breast cancer, lung cancer and colorectal cancer. They are estimated to account for 50% of all new cancer diagnoses in women in 2020.
The increase in breast cancer is related to the ionic entry of oxalate into the fat pad of the breasts.
In this study the results demonstrate a positive correlation between urinary oxalate derived from endogenous oxalate synthesis and body mass index (BMI), as well as other measures of obesity. This also provides an explanation for the association between stone risk and obesity.
https://www.auajournals.org/doi/abs/10.1097/01.JU.0000555369.35715.83 (2019)
On the other hand, insulin resistance and obesity are related to inflammation and immune responses play an important role in the progression of prostate cancer. The cytotoxic function of NK cells for prostate cancer cells is inhibited by humoral factors in adipocytes. These local inflammatory cells are orchestrated by various signals from immune cells, fat cells, or prostate cancers. Prostate cancer cells stimulated by adipokines or saturated fatty acids could change the local immune profile in the context of obesity. Another possible mechanism to affect prostate cancer in obesity could be a gut microbiome. The high-fat diet changes the gut microbiome and improves colorectal cancer and liver cancer. The microbiome could modulate the host's immune system, and these changes in the immune system could have an effect on prostate cancer at a distance. Interventions to address systemic and/or local inflammation and a change in lifestyle may be therapeutic for prostate cancer
https://www.mdpi.com/2077-0383/8/2/201 (2019)
Common plant compounds that cause leaky gut include: Oxalates Histamines, Phytic acid, Lectins. Furthermore, a large proportion of grains, spices and nuts are contaminated with bacteria and mycotoxins (toxic moulds) which are also implicated in intestinal permeability.
https://www.doctorkiltz.com/foods-that-cause-leaky-gut/ (2022)
Studies of the underlying epigenetic and molecular pathways reviewed in this chapter show that nickel compounds are both genotoxic and epigenotoxic, especially when cells are chronically exposed for prolonged periods of up to several weeks to allow sufficient nickel uptake. , with some lingering effects even after withdrawal. from exposure to nickel.
https://www.sciencedirect.com/science/article/pii/B9780128229460000222
The excess of exogenous oxalates associated with the alteration of the AGXT (alanine-glyoxylate aminotransferase) gene encodes an enzyme that breaks down glyoxylate to the amino acid glycine, and when the enzyme is missing or decreased, glyoxylate is converted to oxalate.
Unfortunately, the inability to remove oxalates from your body can contribute to some serious (and painful!) health conditions, including: gout, kidney stones. joint pain and inflammation (similar to fibromyalgia or arthritis), insomnia, anxiety and depression, gastrointestinal problems. thyroid dysfunction, autoimmune disease. chronic inflammation, chronic candida, copd/asthma
Excess oxalates can also lead to oxidative damage and depletion of glutathione (your body's primary antioxidant and detoxifier). This can impair your ability to repair DNA and detoxify, resulting in cell mutation and heavy metal buildup! Also in the link problems related to histamine.
https://discover.grasslandbeef.com/blog/genes-diet-histamines-oxalates-part-5/ (2021)
Great information, thanks!
There go the almond flour cookies and almonds.
Back to taking lemon juice like I did 20 years ago..
This is a good interview...
I am into real meat...Beef....90% and after eating beef and no vegetables I feel GREAT.....lost a lot of weight..pant size from 40 waist to now 34....lost a lot of bloat and sugar craving..and need to snack.....all gone. and I have not changed my way of life...except just started eating meat slowly eliminated the other stuff....now its beef some fruit and milk and honey....facts are I feel pretty good !!! and Im only 75.....
This is more of History in which I eat up >>> https://www.bitchute.com/video/Q5LbZK1a2Wxw/
Here's the interview from Nov 2019 Dr. Mercola refers to... It is also very informative.
https://www.bitchute.com/video/BhEFkf05Ba3P/
Doesn't milk actually make calcium leak from your bones and that's why people who had drunken milk scored high in calcium? And would citrate help with lectins in the almond milk?
Dr., this story needs an adendum.
Here is what Morley Robbins (Root Cause Protocol) says:
"I believe a body struggling w/ LOW Bioavailable Copper simply stores Oxalate><Iron in the Tissue as it LACKS the ANTI-OXIDANT capacity, NOR THE ENERGY to remove the excess Iron...
In the Plant world, plants USE Oxalates to BIND UP excess Iron & dissolve Oxalates w/ an Enzyme, Oxalate Oxidase. The STRONGEST Oxidase in the Body is Ceruloplasmin, which will be low if you have High Iron & Low Copper..."