We know that intestinal dysbiosis, defined by an alteration in the composition of the intestinal microbiota and the reduction of its diversity, is associated with intestinal and extraintestinal conditions, such as irritable bowel syndrome, inflammatory bowel disease, celiac disease, colorectal cancer. , metabolic disorders (obesity and type 2 diabetes), Alzheimer's and Parkinson's diseases and other pathologies.
In this study, gut microbiota diversity was significantly lower in patients with adenomyosis. Furthermore, the analysis showed that the composition of the intestinal microbiota differs between patients with adenomyosis and controls. Patients with adenomyosis presented a reduction of the Bifidobacterium genus in the intestinal microbiota compared to the control group. Bifidobacterium is known to have beneficial effects such as the production of short-chain fatty acids (SCFAs), the formation of biological barriers, and the secretion of antimicrobial compounds. Most of the other bacterial taxa depleted in the adenomyosis group are important butyrate producers and some have also been found to be reduced in the inflammatory bowel disease, Crohn's disease. disease, and endometriosis. Butyrate is a SCFA found in the intestinal metabolome that serves as a crucial energy source for enterocytes and stimulates the growth of the intestinal epithelium, repairing and strengthening the intestinal barrier. A decrease in the abundance of taxa responsible for butyrate production can lead to compromised epithelial cell integrity, increased colonic permeability, bacterial infiltration, and local inflammation.
Strobolome has been considered to contribute significantly to adenomyosis and endometriosis by deregulating circulating estrogen levels in women, through gut microbial enzymes involved in its metabolism. In particular, beta-glucuronidase, beta-galactosidase and beta-glucosidase are bacterial hydrolytic enzymes that play a key role in the deconjugation of estrogens leading to an increase in estrogen. Many studies have shown that inflammatory, angiogenic, growth and hormonal factors may play an important role in the development of adenomyosis. As Dr. Mercola reports, prolonged exposure to estrogen may be a contributing factor to adenomyosis. Bacterial taxa are Gram-negative and, therefore, are characterized by having lipopolysaccharide (LPS) as the main component of their outer membrane. LPS functions as a powerful endotoxin and its activation of pattern recognition receptors, such as the toll-like receptor, plays a crucial role in eliciting pro-inflammatory and immune responses, as well as promoting neoangiogenesis and the secretion of growth factors. It is known that all of these mechanisms are involved in the pathogenesis of adenomyosis. The composition of the intestinal, vaginal and endometrial microbiota of patients with adenomyosis is a factor of important evidence in adenomyosis. Probiotics are beneficial for health and, according to studies in humans and animals, they act to eliminate female gynecological disorders such as vaginal infections, polycystic ovary syndrome, adenomyosis and endometriosis.
We know that intestinal dysbiosis, defined by an alteration in the composition of the intestinal microbiota and the reduction of its diversity, is associated with intestinal and extraintestinal conditions, such as irritable bowel syndrome, inflammatory bowel disease, celiac disease, colorectal cancer. , metabolic disorders (obesity and type 2 diabetes), Alzheimer's and Parkinson's diseases and other pathologies.
In this study, gut microbiota diversity was significantly lower in patients with adenomyosis. Furthermore, the analysis showed that the composition of the intestinal microbiota differs between patients with adenomyosis and controls. Patients with adenomyosis presented a reduction of the Bifidobacterium genus in the intestinal microbiota compared to the control group. Bifidobacterium is known to have beneficial effects such as the production of short-chain fatty acids (SCFAs), the formation of biological barriers, and the secretion of antimicrobial compounds. Most of the other bacterial taxa depleted in the adenomyosis group are important butyrate producers and some have also been found to be reduced in the inflammatory bowel disease, Crohn's disease. disease, and endometriosis. Butyrate is a SCFA found in the intestinal metabolome that serves as a crucial energy source for enterocytes and stimulates the growth of the intestinal epithelium, repairing and strengthening the intestinal barrier. A decrease in the abundance of taxa responsible for butyrate production can lead to compromised epithelial cell integrity, increased colonic permeability, bacterial infiltration, and local inflammation.
Strobolome has been considered to contribute significantly to adenomyosis and endometriosis by deregulating circulating estrogen levels in women, through gut microbial enzymes involved in its metabolism. In particular, beta-glucuronidase, beta-galactosidase and beta-glucosidase are bacterial hydrolytic enzymes that play a key role in the deconjugation of estrogens leading to an increase in estrogen. Many studies have shown that inflammatory, angiogenic, growth and hormonal factors may play an important role in the development of adenomyosis. As Dr. Mercola reports, prolonged exposure to estrogen may be a contributing factor to adenomyosis. Bacterial taxa are Gram-negative and, therefore, are characterized by having lipopolysaccharide (LPS) as the main component of their outer membrane. LPS functions as a powerful endotoxin and its activation of pattern recognition receptors, such as the toll-like receptor, plays a crucial role in eliciting pro-inflammatory and immune responses, as well as promoting neoangiogenesis and the secretion of growth factors. It is known that all of these mechanisms are involved in the pathogenesis of adenomyosis. The composition of the intestinal, vaginal and endometrial microbiota of patients with adenomyosis is a factor of important evidence in adenomyosis. Probiotics are beneficial for health and, according to studies in humans and animals, they act to eliminate female gynecological disorders such as vaginal infections, polycystic ovary syndrome, adenomyosis and endometriosis.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263283 (2022).--
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369051/ (2022).--
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168261/ (2024).—
https://scholar.utc.edu/honors-theses/478/ (2024).—
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301998/ (2023).—
https://journals.sagepub.com/doi/10.1177/17455057241234524?icid=int.sj-full-text.similar-articles.3 (2024).--